Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’

Chemical composition of essential oils and in vitro antioxidant activity of fresh and dry leaves crude extracts of medicinal plant of Lactuca Sativa L. native to Sultanate of Oman

“…The majority of the researchers have reported that the major chemical constituents in the essential oils from the medicinal plant origin are monoterpenes and sesquiterpenes hydrocarbons and their oxygenated derivatives. These monoterpenes and sesquiterpenes hydrocarbons and their oxygenated derivatives have low molecular weight organic volatiles and enormous potential to strongly exhibit microbial pathogens [3][4][5]12] . But in most of cases the antimicrobial ingredients in the essential oils are terpene derivatives, which are almost phenolic in character.…”

“…These secondary metabolic products or compounds are not essential for cell structure and maintenance of life but often involved in plant protection against biotic or abiotic stresses. Natural products, as essential oils, as pure compounds or as standardized extracts, provide unlimited opportunities for the preparation of new drug discoveries because of the unmatched availability of chemical diversity inside the sources [7][8][9][11][12][13] . This paper reports the isolation and GC-MS analysis of the essential oils from the fresh and dry leaves of lettuce grown in Sultanate of Oman.…”

“…It is converted to α,α-diphenyl-β-picrylhydrazine with colour change. The gradually colour change indicates the scavenging activities of the plant crude sample due to bioactive compounds such as phenolic compounds, flavonoids, terpenoids and derivatives [3][4][5]10,12] . In the present study, five different plant crude extracts extracted from Omani lettuce were able to decolorize DPPH.…”

Antibacterial activity of leaves extracts of Trifolium alexandrinum Linn. against pathogenic bacteria causing tropical diseases

“…Exceptional ways to available antibiotics for disease management have been increasingly felt due to the increase in the resistance of bacterial isolates. This has urgently demanded the requirement of second and third line drug and plants are considered potent candidates to overcome such inevitable problems associated with the complications of antimicrobial resistant bacteria [3][4][5][6][7][8][9][10][11][12] .…”

Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus

“…Although the active constituents may occur in lower concentrations, plant extracts may be a better source of antimicrobial compounds than synthetic drugs (Cox and Balick, 1994). The phenomenon of additive or synergistic effects is often crucial to bioactivity (Aqil et al, 2006a;Kamatou et al, 2006) in plant extracts and in some cases, the activity is lost in purified fractions (Cos et al, 2006). Development of bacterial resistance to synergistic drug combinations, such as those found in plants, may be slower than for single drug therapies.…”