Anti-infective, anti-inflammatory and antipyretic activities of the bulb extracts of Crinum jagus (J. Thomps.) Dandy (Amaryllidaceae)

Minkah, Prince Amankwah Baffour; Danquah, Cynthia Amaning

doi:10.1016/j.sciaf.2021.e00723

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Ethnopharmacological studies have shown that plants from the Amaryllidaceae family such as garlic, onions and bulbs of harmattan lily ( Crinum jagus ) are being used in Ghana for various respiratory tract conditions such as cough, asthma and even tuberculosis. This includes Allium sativum (bulb) and Allium cepa (bulb and leaves) [ 11 , 12 ]. Extracts and isolated compounds from this genus have also shown promising effects as inhibitors of efflux pumps and bacterial biofilms [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

et al. 2021

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The bulbs of Allium species are a known source of antibacterial phytochemicals. Anti-infective, efflux pump and biofilm inhibitory activities of bulb extracts of selected Ghanaian shallots Allium cepa var aggregatum were evaluated using the HT-SPOTi assay and other whole-cell phenotypic screening techniques to determine their possible mechanisms of action. Ethanol and aqueous extracts of white A. cepa inhibited the growth of Mycobacterium smegmatis mc2 155 and Escherichia coli, respectively. The majority of the Allium extracts significantly (p < 0.05) exhibited efflux pump inhibitory activity against all the acid-fast, Gram-positive and Gram-negative strains used. Hexane and chloroform extract of the pink A. cepa and the aqueous extract of the white A. cepa significantly inhibited M. smegmatis biofilm formation. For Pseudomonas aeruginosa, the inhibition was observed at 250 µg/mL for the aqueous extract (~77.34%) and 125 µg/mL for the hexane extract (~76.51%). The results suggest that Ghanaian shallots could potentially be useful when further developed to tackle antimicrobial resistance, particularly in tuberculosis (TB).

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Section: Introductionmentioning

confidence: 99%

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

et al. 2021

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“…The ethanolic extract of C. asiaticum demonstrated significant analgesic effect in an acetic-acid-induced writhing test [ 292 ]. Antipyretic and anti-inflammatory properties of C. jagus were recently reported by Minkah and Danquah [ 291 ]. Leaf extract of C. bulbispermum has also been established to possess antinociceptive effects [ 293 , 294 ].…”

Section: The Genus Crinummentioning

confidence: 97%

“…The anti-inflammatory and the analgesic properties of various Crinum species have been investigated by several authors. The anti-inflammatory effect of C. asiaticum as well as its effect on bradykinin-induced contractions on isolated uterus has been reported [ 288 , 289 , 290 , 291 ]. The ethanolic extract of C. asiaticum demonstrated significant analgesic effect in an acetic-acid-induced writhing test [ 292 ].…”

Section: The Genus Crinummentioning

confidence: 99%

“…The in vitro antitubercular effects of C. asiaticum on Mycobacterium tuberculosis ( M. tuberculosis ) surrogate, Mycobacterium smegmatis ( M. smegmatis ), were reported [ 291 , 304 ]. C. asiaticum was shown to possess a broad-spectrum antimicrobial activity against Gram-positive, Gram-negative bacteria and fungal pathogens [ 291 , 299 ]. Antifungal activities of the essential oil and extracts of C. asiaticum against pathogenic fungi have also been established [ 305 , 306 ].…”

Section: The Genus Crinummentioning

confidence: 99%

“…Dichloromethane extract of C. asiaticum was found to be the most effective against selected oral and vaginal Candida species [ 309 ]. Minkah and Danquah again demonstrated the antimicrobial activity of extracts of C. jagus against clinically significant microorganisms in the High-throughput spot culture growth inhibition (HT-SPOTi) assay [ 291 ]. Water/Ethanol extract of C. jagus was observed to be active on Shigella flexneri -induced diarrhea in rats [ 310 ].…”

Section: The Genus Crinummentioning

confidence: 99%

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The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

et al. 2022

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Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.

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The protective effects of Zingiber zerumbet rhizome against fevers in rats

Mohd Salleh,

Ablat,

Chong

et al. 2024

Sci Nat

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Anti-infective, anti-inflammatory and antipyretic activities of the bulb extracts of Crinum jagus (J. Thomps.) Dandy (Amaryllidaceae)

Cited by 5 publications

References 27 publications

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

Investigating Ghanaian Allium Species for Anti-Infective and Resistance-Reversal Natural Product Leads to Mitigate Multidrug-Resistance in Tuberculosis

The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

The protective effects of Zingiber zerumbet rhizome against fevers in rats

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