Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implants

Webster, Thomas J.; Patel, Alpesh A.; Rahaman, Mohamed N.; Bal, B. Sonny

doi:10.1016/j.actbio.2012.07.038

Cited by 211 publications

(140 citation statements)

References 67 publications

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“…12,13 Inspired by cicada wings, which are covered with nanopillar-shaped structures that are capable of killing bacteria through physical means rather than by using drug, scientists have discovered a way to reduce bacteria growth. [14][15][16][17][18][19][20][21][22] Specifically, studies have shown that when bacteria land on such nanopillar surfaces with features much smaller than the bacteria themselves, bacterial membranes are ruptured.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial properties of PEKK for orthopedic applications

Wang¹,

Bhardwaj²,

Webster³

2017

IJN

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Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth. In this study, a nanostructured surface was fabricated on poly-ether-ketone-ketone (PEKK), a new orthopedic implant chemistry, comprised of nanopillars with random interpillar spacing. Specifically, after 5 days, when compared to the orthopedic industry standard poly-ether-ether-ketone (PEEK), more than 37% less Staphylococcus epidermidis were found on the PEKK surface. Pseudomonas aeruginosa attachment and growth also decreased 28% after one day of culture, with around a 50% decrease after 5 days of culture when compared to PEEK. Such decreases in bacteria function were achieved without using antibiotics. In this manner, this study demonstrated for the first time, the promise that nanostructured PEKK has for numerous anti-infection orthopedic implant applications.

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Section: Introductionmentioning

confidence: 99%

Antibacterial properties of PEKK for orthopedic applications

Wang¹,

Bhardwaj²,

Webster³

2017

IJN

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“…4 In a study of intervertebral fusion, the osseointegration efficiency of PEEK-Cage was lower than that of Ti-Cage. 5 Webster et al 6 implanted machined PEEK in a skull defect and found the bone contact ratio was only approximately 8%. In a clinical study, the combined use of bone morphogenetic protein-2 (BMP-2) with PEEK increased the fusion rate (FR) to 90.6%, 7 while the FR of pure PEEK was only 70.6%.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Tang

et al. 2016

IJN

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“…It exists naturally in small quantities in a water-soluble form, but is most often found in an insoluble form. 6 Orthosilicic acid (Si[OH] 4 ), a soluble form of silicon, does not affect the synthesis of type I collagen for bone tissue regeneration, whereas an Silicon nitride is resistant to bacterial infection during bone regeneration, 9 and silicon increases the proliferation and osteogenic differentiation of osteoblast-like cells. 10 In addition, silica-based bioglass ceramics and biosilicates enhance bone-like structure formation.…”

Section: Introductionmentioning

confidence: 99%

Silica nanoparticles increase human adipose tissue-derived stem cell proliferation through ERK1/2 activation

Kim¹,

Joe²,

Kim³

et al. 2015

IJN

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Background Silicon dioxide composites have been found to enhance the mechanical properties of scaffolds and to support growth of human adipose tissue-derived stem cells (hADSCs) both in vitro and in vivo. Silica (silicon dioxide alone) exists as differently sized particles when suspended in culture medium, but it is not clear whether particle size influences the beneficial effect of silicon dioxide on hADSCs. In this study, we examined the effect of different sized particles on growth and mitogen-activated protein kinase signaling in hADSCs. Methods Silica gel was prepared by a chemical reaction using hydrochloric acid and sodium silicate, washed, sterilized, and suspended in serum-free culture medium for 48 hours, and then sequentially filtered through a 0.22 μm filter (filtrate containing nanoparticles smaller than 220 nm; silica NPs). hADSCs were incubated with silica NPs or 3 μm silica microparticles (MPs), examined by transmission electron microscopy, and assayed for cell proliferation, apoptosis, and mitogen-activated protein kinase signaling. Results Eighty-nine percent of the silica NPs were around 50–120 nm in size. When hADSCs were treated with the study particles, silica NPs were observed in endocytosed vacuoles in the cytosol of hADSCs, but silica MPs showed no cell entry. Silica NPs increased the proliferation of hADSCs, but silica MPs had no significant effect in this regard. Instead, silica MPs induced slight apoptosis. Silica NPs increased phosphorylation of extracellular signal-related kinase (ERK)1/2, while silica MPs increased phosphorylation of p38. Silica NPs had no effect on phosphorylation of Janus kinase or p38. Pretreatment with PD98059, a MEK inhibitor, prevented the ERK1/2 phosphorylation and proliferation induced by silica NPs. Conclusion Scaffolds containing silicon dioxide for tissue engineering may enhance cell growth through ERK1/2 activation only when NPs around 50–120 nm in size are included, and single component silica-derived NPs could be useful for bioscaffolds in stem cell therapy.

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Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implants

Cited by 211 publications

References 67 publications

Antibacterial properties of PEKK for orthopedic applications

Antibacterial properties of PEKK for orthopedic applications

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Silica nanoparticles increase human adipose tissue-derived stem cell proliferation through ERK1/2 activation

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