Anti-infective Agents

Padberg, Stephanie

doi:10.1016/b978-0-12-408078-2.00007-x

Cited by 11 publications

(7 citation statements)

References 289 publications

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“…Anti-infective agents, including anti-bacterial, anti-fungal, anti-viral, and anti-parasitic agents, have been employed to treat different infectious diseases such as severe acute respiratory infections (coronaviruses: SARS-CoV-2/COVID, SARS-CoV, and MER), HIV infection caused by various pathogenic agents, i.e., viruses, bacteria, fungus, and parasites [ 132 , 133 ]. The first NCs-based product to receive US FDA approval for the treatment of fungal infection was orally administered Gris-PEG, which was manufactured by Recro Gainesville LLC (Gainesville, FL, USA) in 1998 and approved for oral administration of the anti-fungal drug griseofulvin to treat ringworm infection.…”

Section: Drug Nanocrystals (Ncs)mentioning

confidence: 99%

Approved Nanomedicine against Diseases

Jia

Jiang

et al. 2023

Pharmaceutics

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Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one of the most effective approaches in elevating a drug‘s treatment efficacy and reducing toxicity by improving drug solubility, altering biodistribution, and controlling the release. The development of nanotechnology and materials has brought a profound revolution to medicine, significantly affecting the treatment of various major diseases such as cancer, injection, and cardiovascular diseases. Nanomedicine has experienced explosive growth in the past few years. Although the clinical transition of nanomedicine is not very satisfactory, traditional drugs still occupy a dominant position in formulation development, but increasingly active drugs have adopted nanoscale forms to limit side effects and improve efficacy. The review summarized the approved nanomedicine, its indications, and the properties of commonly used nanocarriers and nanotechnology.

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Section: Drug Nanocrystals (Ncs)mentioning

confidence: 99%

Approved Nanomedicine against Diseases

Jia

Jiang

et al. 2023

Pharmaceutics

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“…Oritavancin is a semisynthetic lipoglycopeptide active against Gram-positive bacteria, MRSA, VRSA, and cocci resistant to vancomycin. Oritavancin can also kill bacteria by interrupting cell wall functions; it is used to treat complicated skin infections [275][276][277]. Dalbavancin is chemically derived from A-40926, a natural compound produced by the actinomycete Nonomuria spp [278].…”

Section: Amp With Antibacterial Effectsmentioning

confidence: 99%

Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides

et al. 2021

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Antimicrobial peptides (AMPs) are widespread in multicellular organisms. These structurally diverse molecules are produced as the first line of defense against pathogens such as bacteria, viruses, fungi, and parasites. Also known as host defense peptides in higher eukaryotic organisms, AMPs display immunomodulatory and anticancer activities. During the last 30 years, technological advances have boosted the research on antimicrobial peptides, which have also attracted great interest as an alternative to tackling the antimicrobial resistance scenario mainly provoked by some bacterial and fungal pathogens. However, the introduction of natural AMPs in clinical trials faces challenges such as proteolytic digestion, short half-lives, and cytotoxicity upon systemic and oral application. Therefore, some strategies have been implemented to improve the properties of AMPs aiming to be used as effective therapeutic agents. In the present review, we summarize the discovery path of AMPs, focusing on preclinical development, recent advances in chemical optimization and peptide delivery systems, and their introduction into the market.

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“…Penicillins, macrolides, and cephalosporins are thought to have the best safety profile in pregnancy with erythromycin the oral antibiotic most commonly used for acne in pregnancy [18]. But tetracyclines should not be used during pregnancy, as use in the second and third trimester can cause discoloration of teeth and bones [20].…”

Section: Antibioticsmentioning

confidence: 99%

“…Only, erythromycin estolate is not recommended in pregnancy because of potential risk of reversible hepatotoxicity which is rarely reported with other ester forms. The common side effect of erythromycin is gastrointestinal dyspepsy and rarely increasing serum levels of medications metabolized by cytochrome p450 enzymes [20].…”

Section: Antibioticsmentioning

confidence: 99%

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Acneiform Eruptions and Pregnancy

Kaptanoğlu¹,

Mullaaziz²

2017

Acne and Acneiform Eruptions

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Acne and acneiform eruptions during pregnancy need special attention. The physician should be aware of the special condition of a pregnant patient. Acne treatments may aim to prevent worsening, secondary infections, scarring and lowering self-esteem of the mother. However, the treatment of acne and acneiform eruptions are not easy to treat during pregnancy. First, because many cosmetics and procedures are not tested on pregnant patients and it is impossible to predict the possible consequences of the procedures on fetus, many women quit cosmetic procedures during pregnancy. Second, the underlying conditions such as hormonal influx and immunosuppression continue. Third, the medications for acne have limitations due to the lack of evidence of safety during pregnancy. Here, a acneiform eruptions during pregnancy, including acne vulgaris, acne rosacea, perioral dermatitis, and hidradenitis suppurativa, are reviewed focusing on these points and each of them is evaluated by clinical presentation, differential diagnosis and treatment options focusing on maternal and fetal safety.

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Anti-infective Agents

Cited by 11 publications

References 289 publications

Approved Nanomedicine against Diseases

Approved Nanomedicine against Diseases

Discovery, Optimization, and Clinical Application of Natural Antimicrobial Peptides

Acneiform Eruptions and Pregnancy

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