Anti-Infectious Agents against MRSA

Koyama, Nobuhiro; Inokoshi, Junji; Tomoda, Hiroshi

doi:10.3390/molecules18010204

Cited by 51 publications

(34 citation statements)

References 52 publications

(73 reference statements)

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“…This information is contained in the mecA gene responsible for encoding an altered PBP (PBP2a). 2,3 Until the early 1990s, MRSA isolates were restricted to hospitals. Currently, however, MRSA is no longer exclusively associated with healthcare infections.…”

Section: Introductionmentioning

confidence: 99%

MRSA from Santa Catarina State, Southern Brazil: intriguing epidemiological differences compared to other Brazilian regions

Silveira

Cunha

Caierão

et al. 2015

The Brazilian Journal of Infectious Diseases

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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most frequently isolated agents in both nosocomial and community settings. It is a constant challenge for antibacterial therapy. Therefore, it becomes essential to understand the epidemiology of MRSA isolates in the institution and/or region to guide empirical therapy. The objective of this study was to evaluate the epidemiological characteristics of MRSA isolates in the state of Santa Catarina, Brazil, and determine if there is a clonal spread. We evaluated 124 clinical isolates of MRSA obtained from various anatomical sites from patients in the state of Santa Catarina in Southern Brazil. The antimicrobial susceptibility profile was evaluated by disk diffusion and minimum inhibitory concentration (MIC) was determined by Etest and broth macrodilution. SCCmec types were determined by multiplex PCR and the clonal relationship among isolates was assessed by pulsed field gel electrophoresis. Antimicrobials that have demonstrated lower rates of resistance were tetracycline (20.2%), sulfamethoxazole-trimethoprim (20.2%) and chloramphenicol (12.9%). We did not detect any resistance to glycopeptides, daptomycin, linezolid, and tigecycline. SCCmec type III was predominant (54%), followed by type II (21.8%), consistent with other Brazilian studies. Twenty-six clones were observed grouping 72 (58%) isolates and no clonal relationship was observed between our isolates and the major epidemic clones circulating in Brazil. An intriguing distinct MRSA epidemiology was observed in Santa Catarina, compared to other Brazilian regions.

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Section: Introductionmentioning

confidence: 99%

MRSA from Santa Catarina State, Southern Brazil: intriguing epidemiological differences compared to other Brazilian regions

Silveira

Cunha

Caierão

et al. 2015

The Brazilian Journal of Infectious Diseases

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“…This knowledge may contribute not only to the adoption of effective measures to control the infection, but also to the development of new anti-infective drugs that inhibit bacterial growth plus control virulence [12,15].…”

Section: Introductionmentioning

confidence: 99%

Molecular and phenotypic characteristics of methicillin-resistant Staphylococcus aureus isolated from hospitalized patients

Oliveira

Morey

Santos

et al. 2015

J Infect Dev Ctries

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Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of infections acquired in both community and hospital settings. In this study, MRSA isolated from different sources of hospitalized patients was characterized by molecular and phenotypic methods. Methodology: A total of 123 S. aureus isolates were characterized according to their genetic relatedness by repetitive element sequence based-PCR (REP-PCR), in vitro antimicrobial susceptibility profile, SCCmec typing and presence of seven virulence factor-encoding genes. Results: REP-PCR fingerprinting showed low relatedness between the isolates, and the predominance of one specific lineage or clonal group was not observed. All isolates were susceptible to teicoplanin and linezolide. All isolates were resistant to cefoxitin and penicillin, and the majority were also resistant to one or more other antimicrobials. Fifty isolates (41.7%) were intermediately resistant to vancomycin. Most isolates harbored SCCmec type II (53.7%), followed by type I (22.8%), type IV (8.1%) and type III (1.6%). All isolates harbored at least two virulence factor-encoding genes, and the prevalence was as follows: coa, 100%; icaA, 100%; hla, 13.0%; hlb, 91.1%, hld, 91.1%; lukS-PV and lukF-PV, 2.4%; and tst, 34.1%. A positive association with the presence of hla and SCCmec type II, and tst and SCCmec type I was observed. Conclusion: This study showed the high virulence potential of multidrug-resistant MRSA circulating in a teaching hospital. A high prevalence of MRSA showing intermediate vancomycin resistance was also observed, indicating the urgent need to improve strategies for controlling the use of antimicrobials for appropriate management of S. aureus infections.

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“…WTAs are a major polyanionic polymer in the cell walls of S. aureus [121]. Koyama et al [122] discussed several other avenues to target MRSA, including inhibitors of bacterial cell wall peptidoglycan, inhibitors of WTA, and inhibitors of virulence factors such as staphyloxanthin.…”

Section: Treatmentmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus and the Eye: Current Concepts and Management Strategies

Ritterband

2013

Curr Ophthalmol Rep

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Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most important causes of nosocomial infections worldwide. This review explores the history and epidemiology of MRSA infections with a detailed analysis of its molecular subtyping, target populations, virulence factors, and modes of transmission. In addition, it specifically discusses the spectrum of eye diseases caused by MRSA, reviews the current ophthalmic literature, addresses the controversy regarding ophthalmic antibiotic resistance to MRSA, and examines alternative treatment strategies.

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Anti-Infectious Agents against MRSA

Cited by 51 publications

References 52 publications

MRSA from Santa Catarina State, Southern Brazil: intriguing epidemiological differences compared to other Brazilian regions

MRSA from Santa Catarina State, Southern Brazil: intriguing epidemiological differences compared to other Brazilian regions

Molecular and phenotypic characteristics of methicillin-resistant Staphylococcus aureus isolated from hospitalized patients

Methicillin-Resistant Staphylococcus aureus and the Eye: Current Concepts and Management Strategies

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