Anti-IgA antibodies in selective IgA deficiency and in primary immunodeficient patients treated with γ-globulin

Selective IgA Deficiency and Autoimmunity

“…More over, the titer of IgE anti-IgA had a tight temporal correlation with the occurrence of these reactions. This observation has been confirmed [87], but a direct role of these antibodies in the induction of the anaphylactoid transfusion reactions has not yet been proven.…”

The clinical significance of immunoglobulin A deficiency

“…84 Anti-IgA antibodies are usually of the IgG1 subclass and are more common in IgA-de¢cient subjects who are also IgG2 de¢cient. 80,85 Anti-IgA antibodies may be of the IgE isotype leading to true anaphylactic reactions but the actual incidence of such antibodies is unknown. Anti-IgA antibodies are also possibly associated with certain HLA types in IgA-de¢cient healthy individuals.…”

Follow-Up of Anti-IgA Antibodies in Primary Immunodeficient Patients Treated with γ-Globulin

“…IgG and IgM anti-IgA antibodies were determined by sandwich ELISA as described previously [12]. In brief: microtiter U bottom plates (Greiner, Nürtingen, FRG) were coated with human monoclonal purified proteins (3 pg/ml) or IgA, IgA2 (2 pg/ml) in sodium bicarbo nate buffer, pH 9.6 by overnight incubation.…”

“…Patients on IMGG received doses ranging from 50 to 75 mg/kg every fortnight, and for IVGG 200-300 mg/kg Anti-IgA antibodies are found in small amounts in all normal individuals [1]. Elevated levels of these autoantibo dies have been reported in a few normal adults [2,3], pregnant women [4], patients suffering from systemic lupus erythematosus and rheumatoid arthritis [5], selected IgA deficiency [6] and other primary immunodeficient patients (ID) [7], as well as in multitransfused patients [2] and hypo gammaglobulinémies treated with 7-globulin [8][9][10][11][12]. In these cases, a relationship between exogenous IgA admin istration, anti-IgA antibodies and adverse reactions to the therapy has been suggested.…”