Anti-idiotypic monoclonal antibody cancer vaccines

Chapman, Paul B.

doi:10.1016/1044-579x(95)90006-3

Cited by 8 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The idea of using surrogate antigens as immunogens requires that antigenic mimicry, accomplished using amino acids in place of sugars, elicits an immune specificity pattern for the nominal antigen. Anti-idiotypic antibodies 5 and peptides that mimic tumor-associated carbohydrate (TAC) antigens [6][7][8] or their glycosphingolipid constituents 9 have been described. Here, we demonstrate that designed peptides that consist of carbohydratemimicking motifs presented as multiple-antigen peptides (MAPs) are effective at eliciting (primarily) IgM antibody responses in mice that react with neolactoseries-expressing human and murine tumor cells.…”

Section: Researchmentioning

confidence: 99%

Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses

et al. 1999

View full text Add to dashboard Cite

Tumor-associated carbohydrate (TAC) antigens are important targets in cancer vaccine efforts.Carbohydrates are, however, frequently poor immunogens, in that they are T-cell-independent antigens. Molecular mimicry of TAC by peptides is an alternative approach to generating anti-carbohydrate immune responses. Here we demonstrate that peptide mimotopes can elicit antibody responses that cross-react with representative human TAC antigens. Primary immunization with such a multiple antigenic peptide, along with QS-21 as adjuvant, elicits cytotoxic antibodies reactive with naturally occurring forms of TAC expressed on tumor cells, and vaccination of mice with peptide mimotopes reduced tumor growth and prolonged host survival in a murine tumor model.

show abstract