Anti-idiotypic antibodies to anti-DR in patients with rheumatoid arthritis

Savage, Susan; Searles, Robert P.; Troup, Gary M.; Brożek, Celestyn M.

doi:10.1016/0090-1229(87)90005-5

Cited by 7 publications

(8 citation statements)

References 46 publications

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“…However, circulating anti-HLA-DR antibodies (IgM isotype) were seen after immunization with tetanus in normal volunteers (25). Anti-HLA-DR antibodies have also been described in patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and Hodgkin disease (26)(27)(28). The immunoglobulin fraction of sera derived from patients with SLE decreased antigen presentation by macrophages and was correlated with the presence of anti-lymphocyte antibodies (29).…”

Section: Recognition Of Uas Heterodimers By the Anti-ia1f 18-mermentioning

confidence: 99%

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Topham

Nag

Arimilli

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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Section: Recognition Of Uas Heterodimers By the Anti-ia1f 18-mermentioning

confidence: 99%

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Topham

Nag

Arimilli

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

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“…ELISA plates were coated with MAb anti-DR L243 and incubated sequentially with either unabsorbed or absorbed RA sera, followed by goat peroxidase-conjugated goat anti-human IgG (Fc-specific) antibody, and ABTS. Sera 33 and 34 were from a previous study (18). $ P < 0.01 versus inactive disease group; P < 0.05 versus normal subjects.…”

Section: Resultsmentioning

confidence: 99%

“…We previously have demonstrated that anti-id antibodies directed against anti-DR can be detected in RA sera (18). These initial anti-id studies were done using MAb anti-DR L243 as idiotype in the ELISA.…”

Section: Resultsmentioning

confidence: 99%

“…These antibodies have also been reported in systemic lupus erythematosus (SLE) (12-16) and Hodgkin's disease (17). We have also recently demonstrated that antiidiotypic (anti-id) antibodies directed against anti-DR are present in RA sera (18). Therefore, we have investigated the possibility of the existence of an association between clinical disease activity and DR+ T cells, anti-DR, and anti-id antibodies in RA patients.…”

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confidence: 99%

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Network regulation in rheumatoid arthritis. studies of dr+ t cells, anti‐dr, antiidiotypic antibodies, and clinical disease activity

Searles¹,

Savage²,

Brożek³

et al. 1988

Arthritis & Rheumatism

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We prospectively studied rheumatoid arthritis patients with various degrees of clinical disease activity, for the presence of DR+ T cells by flow cytometry, for anti‐DR using immunoblot analysis, and for antiidiotypic (anti‐id) antibodies by enzyme‐linked immunosorbent assay using F(ab′)2 monoclonal antibody anti‐DR L243 as idiotype. DR+ T cells correlated positively with anti‐DR, and anti‐id correlated negatively with both DR+ T cells and anti‐DR. Active clinical disease correlated positively with both DR+ T cells and anti‐DR, and correlated negatively with anti‐id. This DR antigen/anti‐DR/anti‐id network may control disease activity in rheumatoid arthritis patients.

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“…Revell9 hypothesized that the severity of the cellular response in periprosthetic tissues was related to the number of wear particles. Studies have documented that the majority of UHMWPE wear debris is less than 10 μm,10–15 and Ingham and Fisher16 suggested that the concentration of wear volume within a critical size range (0.2–0.8 μm) determined the development of a biological response. Howie et al17 found that large UHMWPE particles injected into rat knees produced a multinucleated giant cell response, whereas particles smaller than 5 μm were associated with a mononuclear macrophage response.…”

Section: Introductionmentioning

confidence: 99%

Morphological characteristics of total joint arthroplasty‐derived ultra‐high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation

Sieving¹,

Wu²,

Mayton³

et al. 2003

J Biomedical Materials Res

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It is recognized that the chronic inflammation in peri-prosthetic tissue that contributes to implant failure frequently is provoked by the presence of wear debris. Some wear debris is inevitable because of the nature of the prosthesis, but not all patients develop severe inflammatory responses. The precise factors that mediate the severity of tissue inflammation to wear debris has yet to be fully defined. Because wear debris retrieved from peri-prosthetic tissue consists of a heterogeneous mixture of materials with various sizes and shapes, this study evaluated the influence of two major physical aspects of ultra-high molecular weight polyethylene (UHMWPE) wear debris (shape and surface texture) using a model of tissue inflammation. UHMWPE debris particulates recovered from 50 peri-prosthetic tissue samples were examined by scanning electron microscopy and categorized into four groups based upon aspect ratio and surface texture of the material. The four groups were defined as: 1) smooth and globular, 2) smooth and fibular, 3) rough and globular, and 4) rough and fibular. Histological analysis and ELISA assays were conducted to evaluate variations in cellular responses and cytokine production between the groups. The strongest expression of tumor necrosis factor alpha and interleukin-1 beta was found in tissues exposed to UHMWPE debris with both a rough surface texture and fibular shape, and this response was significantly elevated over debris particles with a smooth surface texture and globular shape. The data suggest that both shape and texture influence the severity of specific inflammatory responses and that rough debris surface texture exerts a marked effect on adverse tissue responses when combined with particles that have a sharp, elongated shape.

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Anti-idiotypic antibodies to anti-DR in patients with rheumatoid arthritis

Cited by 7 publications

References 46 publications

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Network regulation in rheumatoid arthritis. studies of dr+ t cells, anti‐dr, antiidiotypic antibodies, and clinical disease activity

Morphological characteristics of total joint arthroplasty‐derived ultra‐high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation

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