Anti-<i>N</i>-methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia

Marinova, Zoya; Bausch-Becker, Nikolaus; Savaskan, Egemen

doi:10.1136/bcr-2018-228512

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The mean age of the 47 cases was 26.7 (± 17.8) years, the minimum age was 17 months [34], and the maximum age was 77 years [50]. Thirty-seven cases (78.7%) were women.…”

Section: Resultsmentioning

confidence: 99%

The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry

Kato¹,

Takenaka²,

Matsumoto³

2022

Front. Biosci. (Landmark Ed)

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Background: Although various studies have been conducted on anti-NMDA receptor encephalitis since it was first reported in 2007, few studies have closely examined its clinical course. Methods: We analyzed 47 case reports of anti-NMDA receptor encephalitis that detailed its clinical course. Results: The results of our study supported the clinical course proposed by Iizuka et al. Conclusions: From the results, it is suggested that the phenomenological features understood as indicative of anti-NMDA receptor encephalitis include: (1) antecedent common cold-like symptoms (31.9%) in the prodromal phase, (2) delirium or acute confusional state (65.9%), (3) symptoms considered to be sudden personality changes (40.4%) in the psychotic phase, (4) central hypoventilation (14.9%) in the unresponsive phase, (5) motor disturbances (57.4%), and (6) autonomic symptoms, mainly without fluctuations (48.9%), in the hyperkinetic phase. These features were found to be similar to "primary mental confusion" (confusion mentale primitive) in French psychiatry in the late 19th century. We believe that classical psychiatry can contribute considerably to the interpretation of biological research results.

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“…The mean age of the 47 cases was 26.7 (± 17.8) years, the minimum age was 17 months [34], and the maximum age was 77 years [50]. Thirty-seven cases (78.7%) were women.…”

Section: Resultsmentioning

confidence: 99%

The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry

Kato¹,

Takenaka²,

Matsumoto³

2022

Front. Biosci. (Landmark Ed)

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“…In NMDAR encephalitis, the psychiatric symptoms even precede the appearance of neurologic symptoms (Dalmau et al 2019 ). A typical constellation is an abrupt onset of psychiatric symptoms such as delusions, amnesia or agitation with no prior psychiatric history (Marinova et al 2019 ). In Sansing et al ( 2007 ) described a woman who exhibited a variety of psychiatric symptoms such as mainly behavioral transformations such as aggression and agitation as well as anxiety and even homicidal ideation (Fig.…”

Section: Resultsmentioning

confidence: 99%

Autoimmune encephalitis with psychiatric features in adults: historical evolution and prospective challenge

Hansen

Timäus

2020

J Neural Transm

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Our review aims to delineate the psychiatric spectrum of autoantibody-associated autoimmune encephalitis over time through its discoveries of antibodies. We searched in PubMed for appropriate articles depicting the first appearance and spectrum of psychiatric symptomatology in autoantibody-positive encephalitis for this narrative review. Memory impairment was first associated with autoantibodies against intracellular antigens such as anti-HuD antibodies in 1993. 8 years later, autoantibodies against cell membrane surface antigens such as voltage-gated potassium channels were described in conjunction with memory dysfunction. The spectrum of psychiatric syndromes was amplified between 1990 and 2020 to include disorientation, behavior, cognitive dysfunction, obsessive compulsive behavior and suicidality in encephalitis patients occurring together mainly with antibodies against surface antigens, less so against intracellular antigens. In general, we found no specific psychiatric symptoms underlying specific autoantibody-associated encephalitis. As fundamental data on this issue have not been systemically assessed to date, we cannot know whether our specific findings would remain from systematic studies, i.e., on the association between cerebrospinal fluid N-methyl-D-aspartate receptor antibodies in catatonia. The psychiatric symptomatology overlaps between psychiatric domains and occurs frequently in antibody-positive encephalitis. No specific psychiatric symptoms imply an underlying, specifically autoantibody-associated encephalitis. The psychiatric phenotypology associated with antibody-positive encephalitis has evolved tremendously recently, and this new evidence reveals its relevance for future diagnostic and treatment aspects of autoimmune encephalitis patients.

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Anti-NMDA receptor encephalitis in older adults: A systematic review of case reports

Giné-Serven

Serra-Mestres²,

Martínez-Ramírez

et al. 2022

General Hospital Psychiatry

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Anti-N-methyl-d-aspartate receptor encephalitis in an older patient presenting with a rapid onset of delusions and amnesia

Cited by 3 publications

References 13 publications

The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry

The Phenomenology of Anti-NMDA Receptor Encephalitis: A Comparison with “Primary Mental Confusion” in Late 19th Century French Psychiatry

Autoimmune encephalitis with psychiatric features in adults: historical evolution and prospective challenge

Anti-NMDA receptor encephalitis in older adults: A systematic review of case reports

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