Anti-Hyperuricemic and Uricosuric Potential of <i>Berberis vulgaris</i> in Oxonate-Induced Hyperuricemic Rats

Bilal, Muhammad; Ahmad, Saeed; Rehman, Tayyeba; Ghauri, Aymen Owais; Khalid, Sana; Abbasi, Waheed Mumtaz; Zakki, Shahbaz Ahmad

doi:10.1177/15593258211040329

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…It could be presumed that drugs extracted from this herb may be more beneficial with lesser adverse effects. 25 A limitation of the present study was the time course of treatment: treatment is initiated before the disease pathology is initiated (prophylactic treatment). Drug accumulation is a prerequisite for the desired therapeutic effect.…”

Section: Resultsmentioning

confidence: 98%

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In Vivo Antihyperuricemic Activities of 3,4,5-Tri-O-caffeoylquinic acid, 4,4',6'-Trihydroxy-2'-Methoxychalcone, and Caffeic Acid from the Aerial Parts of Gnaphalium Affine

Jia

Liu

Fan

2023

Pharmaceutical Fronts

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The extract of Gnaphalium affine has been reported to have antihyperuricemic and renal protective effects in vivo. The plant could alleviate acute hyperuricemia by inhibiting the activity of xanthine oxidase (XOD). 3,4,5-Tri-O-caffeoylquinic acid (3,4,5-triCQA), 4,4',6'-trihydroxy-2'-methoxychalcone (Chal), and caffeic acid (CA) were identified as the main ingredients of the plant attributed to the potential to retard XOD activity. However, whether the compounds were the effective ingredient of the plant exerting antihyperuricemic activity remained largely unknown. In this study, an experimental mouse model of hyperuricemia was induced by potassium oxonate and hypoxanthine, and orally administered with 3,4,5-triCQA (10 and 20 mg/kg/d), Chal (20 and 40 mg/kg/d), and CA (40 and 80 mg/kg/d) for 6 consecutive days, respectively. Then, serum urate levels and liver XOD activities were assessed. The liver- or kidney-to body weight ratio was calculated. Allopurinol (AP, 50 mg/kg/d) and benzbromarone (BBR, 10 mg/kg/d) were used as controls. Our data showed that there were 52.7 to 81.0% inhibitions in XOD activities in mice treated with 3,4,5-TriCQA (10 and 20 mg/kg/d), Chal (20 and 40 mg/kg/d), and CA (80 mg/kg/d), and 38.8 to 72.5% reduction in uric acid levels in mice treated with 3,4,5-TriCQA (20 mg/kg/d), Chal (20 and 40 mg/kg/d), and CA (40 and 80 mg/kg/d). A larger kidney-to-body weight ratio was observed in hyperuricemic mice and further enhanced by AP treatment. However, the increasing trend was significantly reversed by additional treatment of 3,4,5-triCQA (10 and 20 mg/kg/d) and CA (40 mg/kg/d). Given the above fundings, 3,4,5-triCQA, Chal, and CA may be the key component responsible for the in vivo activities of G. affine for urate-lowering therapy and even promising agents for the treatment of hyperuricemia.

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Section: Resultsmentioning

confidence: 98%

“…It could be presumed that drugs extracted from this herb may be more beneficial with lesser adverse effects. 25…”

Section: Resultsmentioning

confidence: 99%

In Vivo Antihyperuricemic Activities of 3,4,5-Tri-O-caffeoylquinic acid, 4,4',6'-Trihydroxy-2'-Methoxychalcone, and Caffeic Acid from the Aerial Parts of Gnaphalium Affine

Jia

Liu

Fan

2023

Pharmaceutical Fronts

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“…Results showed that there was XO inhibition with a significant decrease of serum and liver uric acid levels significantly in a dose‐ and time‐dependent manner. In addition, 3‐day and 7‐day administration of B. vulgaris showed more potential compared to 1‐day administrations (Bilal et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mahomoodally,

Coodian,

Hosenally

et al. 2024

Phytotherapy Research

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Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

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Antihyperuricemic and Nephroprotective Effects of the Total Flavonoids from Carya cathayensis Leaves (CCTF) in Potassium Oxonate/hypoxanthine-induced Hyperuricemic Mice

Hao

Zhou

2023

Clinical Complementary Medicine and Pharmacology

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Anti-Hyperuricemic and Uricosuric Potential of Berberis vulgaris in Oxonate-Induced Hyperuricemic Rats

Cited by 6 publications

References 20 publications

In Vivo Antihyperuricemic Activities of 3,4,5-Tri-O-caffeoylquinic acid, 4,4',6'-Trihydroxy-2'-Methoxychalcone, and Caffeic Acid from the Aerial Parts of Gnaphalium Affine

In Vivo Antihyperuricemic Activities of 3,4,5-Tri-O-caffeoylquinic acid, 4,4',6'-Trihydroxy-2'-Methoxychalcone, and Caffeic Acid from the Aerial Parts of Gnaphalium Affine

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Antihyperuricemic and Nephroprotective Effects of the Total Flavonoids from Carya cathayensis Leaves (CCTF) in Potassium Oxonate/hypoxanthine-induced Hyperuricemic Mice

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