Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats

Yang, Qiuxuan; Wang, Qilong; Deng, Wenwen; Sun, Congyong; Wei, Qiuyu; Adu‐Frimpong, Michael; Shi, Jixiang; Yu, Jiangnan; Xu, Ximing

doi:10.1016/j.ijbiomac.2018.11.077

Cited by 47 publications

(24 citation statements)

References 74 publications

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“…A positive coefficient indicates that it is positively correlated with the enzyme activity, while a negative number indicates that it is negatively correlated with the enzyme activity. The IC 50 for XO activity increased with increasing peak areas of 3,4,7,10,11,16,17,18,20,21,23,24,25,26,27,28, and 30, indicating that this component group was positively correlated with XO inhibitory activity and that peaks 1,2,5,6,8,9,12,13,14,15,19,22,31,32, and 33 were negatively correlated with their inhibitory activities ( Figure 6). Variable importance in projection (VIP) scores is important indicators that reflect the ability of independent variables to explain dependent variables.…”

Section: Plsr Analysis Resultsmentioning

confidence: 98%

“…These methods enable rapid analysis, complement their respective advantages, and can be used to comprehensively evaluate the quality of L. lucidum. GRA showed that the main components responsible for the XO inhibitory activity of L. lucidum might be characteristic peaks 1,2,4,5,6,7,8,9,11,12,14,15,16,17,20,21,23,25,27,28,29,31,32, and 33. PLS analysis showed that peaks 1, 2, 4, 5, 6, 7, 14, 17, 22, 24, 25, 28, 31, F I G U R E 6 Effect coefficient of each chromatographic peak on the xanthine oxidase inhibitory activity F I G U R E 7 VIP contribution of each characteristic peak to the antioxidant activity of Ligustrum lucidum and 33 had significant effects on the XO inhibitory activity.…”

Section: Plsr Analysis Resultsmentioning

confidence: 99%

“…The gray relational grade is shown in 4,25,26,27,28,29, and 30 was greater than 0.8, indicating that they had a relatively significant effect on the XO activity. Components 1,2,3,5,6,7,8,9,10,11,12,14,15,16,17,18,19,20,21,22,23,24,31,32, and 33 all had correlation degrees greater than 0.7, indicating a significant effect on the XO activity. Combined with the data in the table, it can be seen that the inhibitory activities of characteristic peaks 1,2,4,5,6,7,8,9,11,12,14,15,16,17,20,21,23,25,27,28,29,…”

Section: F I G U R E 3 Cluster Analysis Of the Ligustrum Lucidum Extrmentioning

confidence: 98%

“…Liu et al [4] isolated 12 glycosides from Stauntonia brachyanthera fruit that were good XO inhibitors with potential antigout effects. Yang et al [5] investigated the antihyperuricemic and anti-gouty arthritis effects of a purified water-soluble polysaccharide (LJP-1) from Lonicera japonica and found that it could obviously decrease the serum uric acid level and suppress XO activity. Overall, research on natural products is an important source of compounds for gout treatment.…”

Section: Introductionmentioning

confidence: 99%

“…XO is present at high concentrations in the gastrointestinal tract and human liver and is responsible for the metabolism of hypoxanthine and xanthine to uric acid accompanied by the production of superoxide anion (O 2− ) in the purine catabolic pathway . Overproduction or underexcretion of uric acid may cause hyperuricemia . Therefore, hyperuricemia is closely related to the level of uric acid in the human body.…”

Section: Introductionmentioning

confidence: 99%

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Study on the spectrum‐effect relationship of the xanthine oxidase inhibitory activity of Ligustrum lucidum

Gao

Chen

Zhou

2019

J of Separation Science

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To evaluate the xanthine oxidase inhibitory activity of the chemical constituents of Ligustrum lucidum in vitro, the spectrum‐effect relationship was investigated. The high‐performance liquid chromatography fingerprint was established by ultraviolet spectrophotometry, and the xanthine oxidase inhibitory activity was tested in vitro by a high‐throughput screening method. Cluster analysis, principal component analysis, gray correlation analysis, and partial least squares regression were used to explore the spectrum‐effect relationships. Sixty batches of Ligustrum lucidum were collected from 16 provinces for testing. The results revealed differences among the batches of medicinal materials, and the similarity score was between 0.635 and 0.968. Thirty‐three characteristic peaks (1–33) were calibrated by fingerprint evaluation software for traditional Chinese medicine. The spectrum‐effect relationship study further revealed that the contents of peaks 1, 2, 4, 5, 6, 7, 14, 17, 25, 28, 31, and 33, which are potentially critical ingredients for quality control of Ligustrum lucidum fruit, were highly correlated with the inhibition of xanthine oxidase activity.

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Section: Plsr Analysis Resultsmentioning

confidence: 98%

Section: Plsr Analysis Resultsmentioning

confidence: 99%

Section: F I G U R E 3 Cluster Analysis Of the Ligustrum Lucidum Extrmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study on the spectrum‐effect relationship of the xanthine oxidase inhibitory activity of Ligustrum lucidum

Gao

Chen

Zhou

2019

J of Separation Science

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Extraction and structural analysis of Angelica sinensis polysaccharide with low molecular weight and its lipid‐lowering effect on nonalcoholic fatty liver disease

Sun

et al. 2020

Food Science & Nutrition

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Nonalcoholic fatty liver disease (NAFLD) is one of the prevalent and typical chronic liver diseases. In this study, we extracted a novel Angelica sinensis polysaccharide (ASP) with low molecular weight (MW) of 3.2 kDa through optimized “one‐step” purification process. The major monosaccharide components of ASP were mannose, rhamnose, glucuronic acid, galactose, arabinose, and xylose with weight ratio of 0.23:0.17:14.41:0.39:1.68:0.87, respectively. Herein, “small” ASP could serve as an effective therapeutic option for NAFLD both in free fatty acid‐induced L02 models and in high‐fat diet‐induced mice models. Results revealed that low MW ASP dose‐dependently decreased TG, TC in vitro and TG, TC, ALT, HDL‐C, and LDL‐C in vivo. Oil Red O‐positive area and Nile red fluorescence intensity decreased in ASP treatment groups both in vitro and in vivo which suggested ASP could reduce lipid accumulation and fatty regeneration. Hematoxylin–eosin staining results shown a decrease in hepatocytes ballooning indicating that ASP could ameliorate liver lipid degeneration. Briefly, a novel polysaccharide with low MW was successfully obtained which can prospectively act as NAFLD therapy.

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Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mahomoodally,

Coodian,

Hosenally

et al. 2024

Phytotherapy Research

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Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

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Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats

Cited by 47 publications

References 74 publications

Study on the spectrum‐effect relationship of the xanthine oxidase inhibitory activity of Ligustrum lucidum

Study on the spectrum‐effect relationship of the xanthine oxidase inhibitory activity of Ligustrum lucidum

Extraction and structural analysis of Angelica sinensis polysaccharide with low molecular weight and its lipid‐lowering effect on nonalcoholic fatty liver disease

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

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