Anti-Hypertensive Effects of Peptides Derived from Rice Bran Protein

Shobako, Naohisa; Ohinata, Kousaku

doi:10.3390/nu12103060

Cited by 13 publications

(9 citation statements)

References 58 publications

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“…Rice bran components have been reported to show anticancerous activity via various mechanisms involving antiapoptosis activity, anti‐inflammatory activity, chemo‐protective action, and so forth (Yu et al, 2019). Other phytoactive compounds of rice bran have also been documented to show other pharmaceutical activities like antidiabetic activity, anti‐inflammation, antihypertensive activity, cholesterol‐lowering activity, antioxidant activity, antimicrobial activity, and others, which elucidates the medicinal significance of rice bran in present time (Agista et al, 2021; Arab et al, 2011; Kahlon et al, 1993; Rao, Sugasini, et al, 2016; Shobako & Ohinata, 2020; Sivamaruthi et al, 2018). Munkong et al (2023) reported that in high‐fat diet‐fed mice, red rice bran extract mitigates the different pathological complications of dyslipidemia and hepatosteatosis by regulating the expression of various major genes involved in apoptosis, oxidative stress, inflammation, and lipid metabolism.…”

Section: Introductionmentioning

confidence: 92%

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

Kumar

Singh

Sharma

2023

eFood

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Rice is an essential crop, growing in nearly every part worldwide. Grains are the most common rice plant part consumed as food; however, other plant parts also have some significant values apart from grains. Rice bran is the outer layer of the rice grain, an excellent source of various phenolic, flavonoid, and phytoactive compounds. This review article discusses the various compounds found in rice bran with their structure and properties. Different medicinal properties of rice bran are also discussed in this review article. Several constituents of rice bran show anticancerous activity through various mechanisms like cell cycle arrest and regulation of apoptotic factors. Anti‐inflammatory, antidiabetic, antihypertensive, and cholesterol‐lowering are the other activities of rice bran, briefly explained in the article, along with their mechanism of action. A bibliographic network, including keyword bibliography analysis and a three‐field plot, has also been discussed to show the trends and network of common keywords in the recently published documents in the Scopus database. Overall, this review explores the rice bran compositions with their structures, activity, and various medicinal uses of rice bran, which can be proven an efficient oil source for nutritional purposes.

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Section: Introductionmentioning

confidence: 92%

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

Kumar

Singh

Sharma

2023

eFood

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“…The peptide (Leucine–Arginine–Alanine) obtained from Oryza sativa and chebulin (Aspartate–Glutamate–Asparagine-Serine–Lysine–Phenylalanine) from Terminalia chebula Retz has shown anti-hypertension activity by inhibiting ACE. The walnut and the fruit of Terminalia chebula Retz have been used as a food supplement in the control the hypertension (Shobako and Ohinata 2020 ; Sornwatana et al 2015 ).…”

Section: Non-infectious Diseasesmentioning

confidence: 99%

The Updated Review on Plant Peptides and Their Applications in Human Health

Mani

Bhatt

Vasudevan

et al. 2022

Int J Pept Res Ther

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“…Thus, ACE inhibitors based on peptides derived from natural products are continuously and vigorously being investigated. In particular, casein from animal products and plant proteins from soybeans inhibit ACE activity in vitro [ 85 , 86 ]. Studies investigating functional foods with positive effects on hypertension are actively being conducted.…”

Section: Bioactivities and Human Health Benefits Of Cgjmentioning

confidence: 99%

Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang

Kim

Hwang

Yang³

et al. 2021

IJMS

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Cheonggukjang (CGJ, fermented soybean paste), a traditional Korean fermented dish, has recently emerged as a functional food that improves blood circulation and intestinal regulation. Considering that excessive consumption of refined salt is associated with increased incidence of gastric cancer, high blood pressure, and stroke in Koreans, consuming CGJ may be desirable, as it can be made without salt, unlike other pastes. Soybeans in CGJ are fermented by Bacillus strains (B. subtilis or B. licheniformis), Lactobacillus spp., Leuconostoc spp., and Enterococcus faecium, which weaken the activity of putrefactive bacteria in the intestines, act as antibacterial agents against pathogens, and facilitate the excretion of harmful substances. Studies on CGJ have either focused on improving product quality or evaluating the bioactive substances contained in CGJ. The fermentation process of CGJ results in the production of enzymes and various physiologically active substances that are not found in raw soybeans, including dietary fiber, phospholipids, isoflavones (e.g., genistein and daidzein), phenolic acids, saponins, trypsin inhibitors, and phytic acids. These components prevent atherosclerosis, oxidative stress-mediated heart disease and inflammation, obesity, diabetes, senile dementia, cancer (e.g., breast and lung), and osteoporosis. They have also been shown to have thrombolytic, blood pressure-lowering, lipid-lowering, antimutagenic, immunostimulatory, anti-allergic, antibacterial, anti-atopic dermatitis, anti-androgenetic alopecia, and anti-asthmatic activities, as well as skin improvement properties. In this review, we examined the physiological activities of CGJ and confirmed its potential as a functional food.

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Anti-Hypertensive Effects of Peptides Derived from Rice Bran Protein

Cited by 13 publications

References 58 publications

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

The Updated Review on Plant Peptides and Their Applications in Human Health

Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang

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