Anti-hypertensive Effects of Izumi-Shrimp Extracts in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP).

Nii, Yoshitaka; Fukuta, Kazuhiro; Yoshimoto, Ryoko; Cui, Yulin; Ushiyama, Yu; Sakai, Kentaro; Yamamoto, Shigeru; Ogawa, Tadashi

doi:10.3136/nskkk.45.671

Cited by 2 publications

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“…5) In the present study, we attempted to isolate the ACE inhibitory peptides derived from the izumi shrimp hydrolysate and also examined the anti-hypertensive effects on SHRSP of these peptides.…”

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“…We have previously found that an izumi shrimp hydrolysate significantly inhibited the age-associated spontaneous increase in blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP). 5) In the present study, we attempted to isolate ACE inhibitory peptides derived from the izumi shrimp hydrolysate and examined the anti-hypertensive effect of these peptides on SHRSP. The antigenicity and allergenicity of the izumi shrimp hydrolysate were also examined against male BALB/c mice sensitized by the izumi shrimp hydrolysate.…”

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Determination of Antihypertensive Peptides from an Izumi Shrimp Hydrolysate

Nii¹,

Fukuta²,

Yoshimoto³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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The izumi shrimp (Plesionika izumiae Omori, 1971) is an unused resource which can be caught off the southern coast of Tokushima Prefecture. We have previously found that an izumi shrimp hydrolysate significantly inhibited the age-associated spontaneous increase in blood pressure in stroke-prone spontaneously hypertensive rats. In this present study, two angiotensin I-converting enzyme inhibitory peptides were isolated from an izumi shrimp hydrolysate by using high-performance liquid chromatography, and their amino acid sequences were determined to be ValTrp-Tyr-His-Thr and Val-Trp. A single oral administration of synthetic Val-Trp-Tyr-His-Thr or Val-Trp significantly decreased the blood pressure in strokeprone spontaneously hypertensive rats. The antigenicity and allergenicity of the izumi shrimp hydrolysate against BALB/c mice were very low. These results demonstrate that the angiotensin I-converting enzyme inhibitory peptides isolated from the izumi shrimp hydrolysate had an anti-hypertensive effect on rats.

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confidence: 99%

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confidence: 99%

Determination of Antihypertensive Peptides from an Izumi Shrimp Hydrolysate

Nii¹,

Fukuta²,

Yoshimoto³

et al. 2008

Bioscience, Biotechnology, and Biochemistry

Self Cite

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“…In some studies, the in vitro inhibition of angiotensin-converting enzyme (ACE) was greater with shrimp protein hydrolysates than with fish protein hydrolysates [18, 19]. Nii et al [20] previously demonstrated that the oral administration of an izumi shrimp ( Plesionika izumiae Omori) hydrolysate significantly inhibited the age-associated spontaneous increase in BP in stroke-prone spontaneously hypertensive rats. The group went on to isolate two ACE inhibitory peptides from the izumi shrimp hydrolysate; their amino acid sequences were determined to be valine-tryptophan-tyrosine-histidine-threonine and valine-tryptophan [21].…”

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confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure

Musa-Veloso

Paulionis

Pelipyagina³

et al. 2019

International Journal of Hypertension

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In this randomized, double-blind, placebo-controlled, multicentre, parallel, 8-week study, the efficacy of a daily dose of 1200 mg of protein hydrolysate from Coldwater Shrimp (Pandalus borealis) on ambulatory and office blood pressure was investigated in 144 free-living adults with mild to moderate hypertension. The primary outcomes of the study were daytime ambulatory systolic blood pressure and office blood pressure. During the 8-week intervention period and in the intention-to-treat analysis (n=144), there were significant reductions in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group in daytime ambulatory systolic blood pressure at 4 weeks (p=0.014) and at 8 weeks (p=0.002), and in office systolic blood pressure at 2 weeks (p=0.031) and 4 weeks (p=0.010), with a trend toward significance at 8 weeks (p=0.087). By 8 weeks, significant and favourable improvements in the group consuming the shrimp-derived protein hydrolysate relative to the placebo group were also observed for several secondary outcomes, including 24-hour ambulatory systolic and diastolic blood pressure, daytime ambulatory diastolic blood pressure, and daytime and 24-hour ambulatory mean arterial pressure. Also by Week 8, there was a statistically significant difference between groups in the distribution of subjects across National Institutes of Health-defined blood pressure categories (i.e., Normotensive, Prehypertensive, Stage 1 hypertension, and Stage 2 hypertension), with a more favourable distribution in the shrimp-derived protein hydrolysate group than in the placebo group (p=0.006). Based on exploratory analyses conducted only in participants in the shrimp-derived protein hydrolysate group, angiotensin II levels were significantly reduced relative to baseline. This study is registered at ClinicalTrials.gov NCT01974570.

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Anti-hypertensive Effects of Izumi-Shrimp Extracts in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP).

Cited by 2 publications

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Determination of Antihypertensive Peptides from an Izumi Shrimp Hydrolysate

Determination of Antihypertensive Peptides from an Izumi Shrimp Hydrolysate

A Randomized, Double-Blind, Placebo-Controlled, Multicentre Trial of the Effects of a Shrimp Protein Hydrolysate on Blood Pressure

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