Anti-hypertensive effects of <i>Callisia fragrans</i> extract on Reno-vascular hypertensive rats

Le, Xoan Thi; Nguyen, Loan Thanh Thi; Nguyen, Phuong; Nguyen, Tai Van; Nguyen, Hiep Van; Pham, Hang Thi Nguyet; Tran, Hong Nguyen; Hoang, Thang Dac; Le, Dong; Matsumoto, Kinzo

doi:10.1080/10641963.2022.2065286

Clinical and Experimental Hypertension

2022

DOI: 10.1080/10641963.2022.2065286

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Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats

Xoan Thi Le¹,

Loan Thanh Thi Nguyen

Phuong Nguyen³

et al.

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Cited by 2 publications

References 14 publications

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PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats

Zhang,

Wei,

Ning

et al. 2024

J. of Cardiovasc. Trans. Res.

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PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats

Zhang,

Wei,

Ning

et al. 2024

J. of Cardiovasc. Trans. Res.

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Antihypertensive and Antioxidant Effects of an Aqueous Extract of Asafetida in Renovascular Hypertensive Rats

Kazemi,

Mohebbati,

Shafei

2023

Saudi Journal of Kidney Diseases and Transplantation

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Recently, the effect of an aqueous extract of asafetida on acute angiotensin II hypertensive rats was evaluated. The present study evaluated the antihypertensive and antioxidant effects of asafetida on a rat model of renovascular hypertension (RVH) using four groups. RVH was induced by clipping the renal artery; the sham group underwent surgery but without clipping. The RVH rats received losartan (Los, an AT1 receptor antagonist) or asafetida by gavage for 4 weeks. On the 28th day, the femoral artery was cannulated, and the systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) were recorded. Finally, the levels of superoxide dismutase (SOD) activity, malondialdehyde (MDA), and total thiol content in the kidney and heart tissues were measured. In RVH rats, SBP and MAP significantly increased compared with the control. Los and the extract significantly reduced the changes in SBP, MAP, and HR that were induced in the RVH rats (P <0.05–0.001). In RVH rats, levels of MDA significantly increased and the content of total thiol and SOD decreased in both the heart and kidney tissues. Los plus the extract significantly decreased MDA and increased total thiol and SOD in the heart and kidney tissues. We concluded that an aqueous extract of asafetida gum has antihypertensive and antioxidant effects in the RVH rat model. The effect of the extract is similar to that of Los, which suggests that this effect of asafetida is mediated via an effect on the angiotensin Type I receptor.

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Anti-hypertensive effects of Callisia fragrans extract on Reno-vascular hypertensive rats

Cited by 2 publications

References 14 publications

PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats

PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats

Antihypertensive and Antioxidant Effects of an Aqueous Extract of Asafetida in Renovascular Hypertensive Rats

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