Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats

Abstract

We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity.

Widely Targeted Metabolomic and Transcriptomic Analyses of a Novel Albino Tea Mutant of “Rougui”

“…L-ascorbate is an organic compound with antioxidant effects, and its green tea extract inhibits atherosclerosis [63]. Here, l-ascorbate and its two synthetically related MIOX genes were found to be significantly changed (Table 3) and the increased level of l-ascorbate is beneficial to the nutritional value of YR. Flavonoids also contribute to the quality of tea [64], and have antioxidative [65], antihypertensive [66], antidiabetic [67], and other activities. It is notable that most of the significantly altered flavones, flavonols, and flavanones showed an obviously increased abundance in YR, suggesting that the albino tea mutant YR may have high application value.…”

Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review

“…Some of these compounds, which are derived from exogenous sources (e.g., polyphenols) may improve the status of the microbiota and may reduce its oxidative stress [2]. Defined as non-nutrients, secondary plant metabolites, antioxidants, or bioactive substances in plants [3], polyphenols represent a class of compounds that has been studied not only because of their biological properties (such as immunomodulatory and anti-inflammatory [4][5][6], cardioprotective [7,8], anti-diabetic and anti-obesity [9,10], anti-cancer [11][12][13], neuroprotective [14,15], anti-asthmatic [16,17], anti-hypertensive [18], anti-aging [8], hepatoprotective [19,20], antibacterial [21,22], anti-fungal, and antiviral [23,24]), but also because they are present in most types of diet. The main sources of polyphenols in the diet include fruits, vegetables, tea, and coffee, but they can also come from the administration of various food supplements.…”

Enzymatic Hydrolysis of Egg White Protein Exerts a Hypotensive Effect in Spontaneously Hypertensive Rats

“…The SHR strain is a suitable rodent model for hypertension. These rats show impaired vascular function and higher levels of Ang II, oxidative stress, and inflammation compared to wild type rats (Ikarashi et al, 2018). The SBP and DBP baselines in all the experimental groups were approximately 140 mmHg and 80 mmHg, respectively, indicating the presence of hypertension, and these values are similar to those in humans with essential hypertension (Okamoto and Aoki, 1963).…”