Abstract:Background and Purpose: Angiotensin receptor-NEP inhibitor (ARNi), which
is consisting of an angiotensin receptor blocker (ARB) and a neprilysin
inhibitor (NEPi), has been proven safe and effective for treating
hypertension. S086 is a novel ARNi cocrystal developed by Salubris for
the treatment of heart failure and hypertension. Rat hypertension model
and telemetry system were used in our study to investigate circadian
rhythm of rat blood pressure and evaluate the anti-hypertensive efficacy
of S086. Experiment… Show more
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