Anti-Hypertensive Action of dl-α-Tocopheryl Esters in Rats

Abstract

1.Oral administration of DL-a-tocopheryl nicotinate (EN) (0.04 or 0.2 mmol day-' kg-I ) or DL-Utocopheryl acetate (EA) (0.2 mmol day-' kg-') delayed the progress of hypertension in unilaterally nephrectomized rats, which were treated with deoxycorticosterone and salt, and in genetically hypertensive rats (SHR) which were given sodium chloride solution. Suppression of body weight gain, incidence of pneumonia and mortality were reduced by treatment with EN or EA.2. Severe hypertension in old SHR (9 months) further progressed, when drinking water was replaced by sodium chloride solution, and four out of ten of these animals died of cerebral haemorrhage during 4 weeks. The administration of EN or EA prevented the increase in blood pressure and incidence of stroke.

Vitamin E Nicotinate

“…In two different studies, Igarishi et al compared the effects of α-tocopheryl nicotinate and α-tocopheryl acetate in rat models of hypertension [37,38]. They demonstrated that treatment with tocopherol esters reduces the progression of hypertension and protects animals from myocardial fibrosis, pulmonary edema, weight loss, and death.…”