Anti-hyperplasia effects of Rosa rugosa polyphenols in rats with hyperplasia of mammary gland

Chen, Tao; Li, Jingjing; Chen, Jinglou; Song, Ho-Young; Yang, Chuhao

doi:10.1016/j.etap.2015.02.014

Cited by 30 publications

(20 citation statements)

References 22 publications

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“…Inflammatory responses can be inhibited by suppressing the phosphorylation of p38 in MAPK signaling pathways. DLCs may exert antihyperplasia effects through anti-inflammatory responses [21]. …”

Section: Resultsmentioning

confidence: 99%

“…The MAPK and TNF signaling pathways are anti-inflammatory pathways, with MAPK14 and TNF as the pivotal targets, respectively [31]. TCM formulae can exert antihyperplasia effects by alleviating inflammatory responses [21]. TCM teaches that stagnation leads to pain, and thus signs and symptoms of pain can be explained by the mechanism of stagnation.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Huang

Tang

Cao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Hyperplasia of mammary glands (HMG) is common in middle-aged women. Danlu capsules (DLCs) can effectively relieve pain and improve clinical symptoms and are safe for treating HMG. However, the active substances in DLCs and the molecular mechanisms of DLCs in HMG remain unclear. This study identified the bioactive compounds and delineated the molecular targets and potential pathways of DLCs by using a systems pharmacology approach. The candidate compounds were retrieved from the traditional Chinese medicine systems pharmacology (TCMSP) database and analysis platform. Each candidate's druggability was analyzed according to its oral bioavailability and drug-likeness indices. The candidate proteins and genes were extracted in the TCMSP and UniProt Knowledgebase, respectively. The potential pathways associated with the genes were identified by performing gene enrichment analysis with DAVID Bioinformatics Resources 6.7. A total of 603 compounds were obtained from DLCs, and 39 compounds and 66 targets associated with HMG were obtained. Gene enrichment analysis yielded 10 significant pathways with 34 targets. The integrated HMG pathway revealed that DLCs probably act in patients with HMG through multiple mechanisms of anti-inflammation, analgesic effects, and hormonal regulation. This study provides novel insights into the mechanisms of DLCs in HMG, from the molecular level to the pathway level.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Huang

Tang

Cao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…A large amount of reactive oxygen species (ROS) was found to be produced by long-term high-estrogen stimulation, which in turn caused oxidative stress injury in mammary gland tissues [ 25 – 27 ]. Given the aforementioned mechanism of mammary gland hyperplasia, estrogen and progestin can be utilized to induce mammary gland hyperplasia in model rats [ 18 , 28 ]. In the present study, model rats with mammary gland hyperplasia induced by estradiol benzoate and progestin exhibited obvious elevation of estrogen level in the serum.…”

Section: Discussionmentioning

confidence: 99%

Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats

You

Sun

Xie

et al. 2017

Oxidative Medicine and Cellular Longevity

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Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.

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“…Changes in serum T-SOD, GSH-PX, and MDA T-SOD and GSH-PX in serum are two enzymes reflecting the ability of the anti-oxide free radical. MDA is one of the most important products of membrane lipid peroxidation and showed the extent to which cells are attacked by the radical (Chen et al, 2015). The serum concentrations: T-SOD, GSH-PX, and MDA are presented in Fig.…”

Section: Groupsmentioning

confidence: 99%

Effects of Deer Antler Base Polypeptide on Hormone-induced Mammary Hyperplasia in Mice

Tao

et al. 2018

FSTR

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The objective of this study is to evaluate the effects and therapeutic mechanism of deer antler base polypeptide on mammary hyperplasia in female mice. A trail was conducted on seventy mice which were divided into seven groups including the groups of control, mock, Chinese traditional medicine, and Western medicine, as well as high-dose, medium-dose, and low-dose of polypeptide from deer antler. A combination of oestrogen-progestin induced the mammary hyperplasia. We used an intraperitoneal injection in a 30 d trial and used intragastric administration to treat the disease for a further four weeks. The body weight, organ coefficient, serum hormone level and oxidation level, as well as the pathological section of breast tissue were assessed. Statistical analysis was performed using factor analysis of variance. Compared with the mock group, the high-dose group could increase the serum T-SOD, and GSH-PX activities and thymus coefficient (P < 0.01), decrease the serum MDA concentration and the coefficient of ovary and uterus (P < 0.01). In addition, the high-dose group had reduced levels of E 2 , PRL, and improved P, and LH as confirmed by ELISA to regulate hormone secretion to normal (P < 0.01). The pathological section of breast tissue produced by HE staining showed that the high-dose group reduced the number of inflammatory cells, glandular secretion, the hyperplasia and dilatation of the duct epithelium, and recovered the atrophic alveolar. The results revealed that deer antler base polypeptide has positive effects in the treatment of HMG and the prevention of breast cancer.

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Anti-hyperplasia effects of Rosa rugosa polyphenols in rats with hyperplasia of mammary gland

Cited by 30 publications

References 22 publications

Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats

Effects of Deer Antler Base Polypeptide on Hormone-induced Mammary Hyperplasia in Mice

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