Abstract:Experimental studies carried out for evaluating the anti-hyperlipidemic properties of rice bran components have given interesting but often contrasting results. Therefore, the current study was initiated to investigate the anti-hyperlipidemic activity of oryzanol (OZ), a commercially-important bioactive phytochemical, isolated from crude rice bran oil (cRBO). OZ was isolated by a two-step solvent crystallization process from cRBO, which was extracted from fresh rice bran by hexane mediated soxhlet extraction. … Show more
“…In addition to those preliminary studies, other research has shown that there is a significant effect of these rice branderived products on improving the lipid profile (Table 6). However, black rice bran extracts reduce the progression of dietary cholesterolinduced atherosclerotic plaque development and cholesterol plasma levels in rabbits [125,126] while decreasing the levels of serum triglycerides and total cholesterol in mice [127].…”
Section: Hypocholesterolaemic Effects Of Rice By-productsmentioning
Our study was centred on the increasing literature associated with rice by-products and main components, especially those intended to combat cancer, improve plasma lipid levels or control the blood glucose levels. Rice byproducts, such as rice straw, rice husks, rice bran, rice germ and broken rice, are extensively abundant agricultural wastes from the rice industry, and the percentage of their production depends on the milling rate and type of rice. Among all rice by-products, rice bran has been extensively studied.It contains phytochemicals such as γ-oryzanol, vitamin E, mainly tocotrienols and dietary fibre. This paper reviews the existing literature on the potential role of rice by-products, focusing not only on the role of rice bran but also on the roles of other rice by-products, such as rice germ and rice husk, in the management of the diseases, investigating their various potential uses in the food industry and all possible properties that may contribute to these effects.
“…In addition to those preliminary studies, other research has shown that there is a significant effect of these rice branderived products on improving the lipid profile (Table 6). However, black rice bran extracts reduce the progression of dietary cholesterolinduced atherosclerotic plaque development and cholesterol plasma levels in rabbits [125,126] while decreasing the levels of serum triglycerides and total cholesterol in mice [127].…”
Section: Hypocholesterolaemic Effects Of Rice By-productsmentioning
Our study was centred on the increasing literature associated with rice by-products and main components, especially those intended to combat cancer, improve plasma lipid levels or control the blood glucose levels. Rice byproducts, such as rice straw, rice husks, rice bran, rice germ and broken rice, are extensively abundant agricultural wastes from the rice industry, and the percentage of their production depends on the milling rate and type of rice. Among all rice by-products, rice bran has been extensively studied.It contains phytochemicals such as γ-oryzanol, vitamin E, mainly tocotrienols and dietary fibre. This paper reviews the existing literature on the potential role of rice by-products, focusing not only on the role of rice bran but also on the roles of other rice by-products, such as rice germ and rice husk, in the management of the diseases, investigating their various potential uses in the food industry and all possible properties that may contribute to these effects.
“…In addition, a significant increase in the level of hepatic antioxidant enzymes showed a high degree of hepatic protection against free radicals. 38 γ-Oryzanol exerts a hypolipidemic effect even when blended with other vegetable oils. Rats fed a diet containing blends of refined groundnut oil having 3%, 5%, or 10% of γ-oryzanol showed a decrease in total cholesterol in serum (7-16%) and in liver (15%), depending on the γ-oryzanol concentration used, when compared to cholesterol levels of the rats fed on pure groundnut oil.…”
Section: Studies On Rbo and Its Components Against Dyslipidemiasmentioning
“…The isolation of OZ from cRBO using a modified two-step crystallization process previously described by Zullaikah et al (2009) has been discussed previously (Ghatak & Panchal, 2012a). The isolated OZ was identified with respect to the standard by melting point determination, thin-layer chromatography (TLC), UV-visible spectrophotometry and high-performance liquid chromatography (HPLC), the results of which have been published recently (Ghatak & Panchal, 2012b).…”
Several studies have implicated the involvement of poor glycemic control and oxidative/nitrosative stress in the development of diabetic neuropathic pain, an important microvascular complication affecting more than 50% of diabetic patients. However, lack of understanding of the underlying etiology, development of tolerance, inadequate relief and possible toxicity associated with classical analgesics warrant the investigation of the novel agents. Therefore, the present study was carried out to investigate the effect of oryzanol (OZ), a commercially-important potent antioxidant component isolated from from crude rice bran oil (cRBO), in streptozotocin (STZ)-induced diabetic neuropathy in rats. After eight weeks, diabetic rats developed neuropathy which was evident from decreased tail-flick latency (thermal hyperalgesia) and increased nociceptive behavior during the formalin test. This was accompanied by decreased motor coordination based on the evaluation of neuromuscular strength. Na + K + ATPase, a biochemical marker associated with the development of diabetic neuropathy, was significantly inhibited in the sciatic nerve of diabetic animals. The activities of antioxidant enzymes and lipid peroxidation levels were significantly elevated in diabetic rats, indicating the involvement of oxidative stress in diabetic neuropathy. Chronic treatment with oryzanol (OZ) (50 and 100 mg/kg) per oral (p.o.) and standard drug glibenclamide (Gl) (10 mg/ kg, p.o.) significantly attenuated the behavioral as well as biochemical changes associated with diabetic neuropathy. The findings provide experimental evidence to the protective effects of OZ on hyperglycemia-induced thermal hyperalgesia and oxidative stress which might be responsible for diabetes induced nerve damage.
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