Anti-hyperglycemic Effect of Khaya senegalensis Stem Bark Aqueous Extract in Wistar Rats

Kolawole, O. T.; Kolawole, SO; Ayankunle, A. A.; Olaniran, O.I.

doi:10.9734/ejmp/2012/934

Cited by 24 publications

(27 citation statements)

References 21 publications

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“…Ethnopharmacological surveys have revealed that the stem bark, root and leaves of the plant are used in the traditional treatment of diabetes, malaria, anemia, diarrhea, gastrointestinal diseases and fever amongst others (11,12). Scientific investigations have revealed the anti-hyperglycemic activity of the aqueous stem bark extract of this plant in a type-1 diabetes model of rats (13) as well as an in vitro a-amylase inhibitory potential (14). However, detailed investigation of the complete antioxidative and a-glucosidase or a-amylase inhibitory activity of the extracts from different parts of this plant has not been conducted to date.…”

mentioning

confidence: 99%

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

Ibrahim

Koorbanally

Islam³

2014

Acta Pharmaceutica

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Antioxidative activity and inhibition of key enzymes linked to type-2 diabetes (a-glucosidase and a-amylase)by Khaya senegalensis , respectively. Enzyme kinetic studies indicated that the butanol fraction is a non-competitive inhibitor for a-glucosidase with an inhibition binding constant K i of 1.30 µg mL -1 and a competitive inhibitor of a-amylase with a K i of 7.50 µg mL -1 . GC-MS analysis revealed that the butanol fraction contained two chromones, p-anilinophenol and 3-ethyl-5-(3-ethyl-(3H)-benzothiazol-2-ylidene)-2-(p-tolylvinylamino)-4-thiazolidinone. Data obtained in the study suggest that the butanol fraction derived from the ethanolic extract of K. senegalensis root possessed excellent antioxidative as well as a-glucosidase and a-amylase inhibitory activities while chromones and/or p-anilinophenol could be the main bioactive compounds responsible for the observed activities.

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mentioning

confidence: 99%

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

Ibrahim

Koorbanally

Islam³

2014

Acta Pharmaceutica

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“…Our findings support previous studies which have also reported antibacterial properties for K. senegalensis extracts from other plant parts. 12,13,16,18 The K. senegalensis bark extracts screened in our study were particularly potent inhibitors of P. mirabilis and P. vulgaris growth, with MIC values of several extracts substantially <500µg/mL. This activity is noteworthy as P. mirabilis has been implicated in urinary tract infections (UTI's) and the induction of rheumatoid arthritis (RA).…”

Section: Discussionmentioning

confidence: 73%

“…8 K. senegalensis bark extracts have potential in the treatment of diabetes and have been reported to have anti-hyperglycemic activity comparable to glibenclamide. 12 Furthermore, K. senegalensis stem bark extracts have been shown to have high antioxidant content, 6 further indicating the therapeutic potential of this species.…”

Section: An Examination Of the Antimicrobial And Anticancer Propertiementioning

confidence: 99%

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Rabadeaux¹,

Vallette²,

Sirdaarta³

et al. 2017

Phcog J

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Background: Khaya senegalensis (Desr.) A. Juss. is a common component of the pharmacopeia's of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test K. senegalensis bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. Materials and Methods: K. senegalensis bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and G. duodenalis growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. Results: K. senegalensis bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against P. mirabilis (MIC values of 185 and 211µg/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of K. pneumoniae and A. baylyi, and were moderate inhibitors (MIC >1000µg/mL) of P. aeruginosa and S. pyogenes growth. The methanolic and subcritical K. senegalensis extracts were also potent inhibitors of G. duodenalis (187 and 328µg/mL, respectively), as well as Caco-2 (268 and 470µg/mL, respectively) and HeLa carcinomas (155 and 174µg/mL, respectively). GC-MS analysis of the SFE extract revealed relative abundances of a variety of mono-and sesquiterpenoids. Furthermore, all K. senegalensis bark extracts were non-toxic in the Artemia franciscana toxicity assay, indicating their safety for therapeutic use. Conclusion: These studies validate traditional African therapeutic usage of K. senegalensis in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.

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“…A dose-dependent increase in blood levels of total protein, urea, globulin and creatinine have been reported in rats by Kolawole et al [37]. These effects were registered at doses of 100 and 200 mg.kg -1 BW administered for 18 days.…”

Section: Effects On Blood Biochemical and Haematological Compoundsmentioning

confidence: 68%

“…According to Kolawole et al [37], the aqueous extract of the bark of K. senegalensis, at 100 and 200 mg.kg -1 body weights during 18 days, increases plasma levels of liver enzymes namely, Aspartate Amino-Transferase (AST), Alanine Amino-Transferase (ALT) and Alkaline Amino-Phosphatase (ALP) in rats. The same effect was recorded by Abubakar et al [12] with much lower doses (10-40 mg.kg -1 BW) administered for 28 days to albinos rats.…”

Section: Effects On Blood Biochemical and Haematological Compoundsmentioning

confidence: 99%

Bioactivity, therapeutic utility and toxicological risks of Khaya senegalensis

Takin

Attindehou

Sèzan

et al. 2013

IJPBR

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Vegetative organs of Khaya senegalensis (Ders.) A. Juss. are widely used in African pharmacopoeia. A review of pharmacological studies, focused on this plant, was carried out, using the available scientific literature. Several studies have revealed its bioactive properties and therefore its medical efficacy. Aqueous and alcoholic extracts of the stem bark and leaves of this plant have shown efficient in the treatment of some bacterial infections. Their widely reported biochemical effects, such as α-amylase activity inhibition, decreasing in bowel motility and in some blood and serum enzyme (Aspartate transferase, Alanine transferase and Alkaline phosphatase) justify indications against diabetes, diarrhea and liver disorders. Antiparasitic properties directed against helminths and coccidian are also attributed to these herbal medicines. However, according to some results recorded in various studies, this plant has a high risk of toxicity in chronic treatment (several weeks). Histotoxic effects (in liver and kidney) resulting in increased of plasma total protein, blood urea and creatinine are reported.

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Anti-hyperglycemic Effect of Khaya senegalensis Stem Bark Aqueous Extract in Wistar Rats

Cited by 24 publications

References 21 publications

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

Antioxidative Activity and Inhibition of Key Enzymes Linked to Type-2 Diabetes (α-Glucosidase and α-Amylase) by Khaya Senegalensis

An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts

Bioactivity, therapeutic utility and toxicological risks of Khaya senegalensis

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