Anti-hyperglycemic and Anti-oxidant activities of Ethanolic extract of Lantana camara Leaves

Abstract

The present study has been undertaken to evaluate In-vivo Anti–hyperglycemic and anti–oxidant activities of ethanolic Lantana camara leaves extract (LCE). The extract was prepared by cold percolation process. Phytochemical screening indicates that the presence of flavanoids, phenols, carbohydrates etc. The Anti-hyperglycemic activity of the extract was studied by In-vivo using Streptozotocin induced diabetes rat models. Glibenclamide was used as a standard drug to compare the blood glucose level. The groups treated with Lantana camara leaves extract at dose 200 and 400 mg/kg prevented the diabetes condition in a dose related manner. LCE and Glibenclamide treated rats showed decreased LPO that is associated with increased activity of SOD and catalase. The increase in the level of lipid peroxides in plasma generally is thought to be the consequence of increased production of and liberation in to the circulation of tissue lipid peroxides due to pathological changes. This action shows the Anti-peroxidative effect of LCE. The results obtained thus suggest that 50% ethanolic Lantana camara leaves extract possesses potent Anti-hyperglycemic and Anti-oxidant activity.

IDENTIFIKASI SENYAWA KIMIA DAN UJI AKTIVITAS INHIBISI ENZIM ?-AMILASE EKSTRAK ETANOL AKAR TEMBELEKAN (Lantana Camara L.)

“…Senyawa tersebut menunjukkan aktivitas anti-oksidan yang baik dan dapat meningkatkan fungsi sel beta dan meningkatkan sekresi insulin dari pulau Langerhans di pankreas yang dapat dianggap sebagai pengobatan alternatif yang baik untuk pasien diabetes. Quercetin dianggap menghasilkan peningkatan level glukokinase sehingga mendorong sintesis glikogen yang mengurangi ekspresi glukosa 6-fosfatase dan ekspresi gen fosfoenolpiruvat karboksi-kinase, sehingga mengakibatkan penghambatan gluconeogenesis (Venkatesh S et al, 2021). Akar tanaman tembelekan terbukti dapat menurunkan glukosa darah secara in-vivo selain itu juga memiliki aktivitas sebagai antiinflamasi (Sulistiani et al, 2016).…”