Anti-hyperglycemic and anti-hyperlipidemic effects of a methanolic extract of Debregeasia salicifolia in Alloxan-induced diabetic albino mice

Abstract

Diabetes mellitus (DM), an endocrine syndrome characterized by high blood glucose levels due to abrogated insulin activity. The existing treatments for DM have side effects and varying degrees of efficacy. Therefore, it is paramount that novel approaches be developed to enhance the management of DM. Therapeutic plants have been accredited as having comparatively high efficacy with fewer adverse effects. The current study aims to elucidate the phytochemical profile, anti-hyperlipidemic, and anti-diabetic effects of methanolic extract D. salicifolia (leaves) in Alloxan-induced diabetic mice. Alloxan was injected intraperitoneally (150 mg kg-1, b.w), to induced diabetes in mice. The mice were divided into three groups (n=10). Group 1 (normal control) received normal food and purified water, Group II (diabetic control) received regular feed and clean water and group III (diabetic treated) received a methanolic extract of the plant (300 mg kg-1) for 28 days with a typical diet and clean water throughout the experiment. Blood samples were collected to checked serum glucose and concentration of LDL, TC, TG. The extract demonstrated significant antihyperglycemic activity (P<0.05), whereas improvements in mice's body weight and lipid profiles were observed after treatment with the extract. This study establishes that the extract has high efficacy with comparatively less toxicity that can be used for DM management.

Reducing Sugar, Alkaloid and Tannin from Dryopteris dilatata Fractions Modulates Diabetogenic and Oxidative Stress Activity on Alloxan Induced Diabetic Rats

“…After daily oral administration of fractions of Dd (800 mg/kg), abnormalities in lipid levels after diabetic induction was adequately reversed as levels of total cholesterol, tryglycerides, low density lipoproteins and very low density lipoproteins level were reduced and high density lipoprotein level was increased which could be associated to elevated levels of the hormone thyroxine that possess the capacity to remove circulating bad cholesterol back to the liver, showing the potency of fractions of Dd in controlling diabetes [27]. Our results correlate with Khan et al, [28] and KOFFI et al, [29] where methanolic extract of Debregeasia salicifolia and Cassia siame adequately managed diabetes and serum lipid profile in alloxan-induced diabetic rats. Reports from researches observed the connection between diabetes mellitus and the generation of reactive species resulting from the action of alloxan on the pancreas and in hampered antioxidant defense showing the potential of lipid peroxidative activity in the development of hyperglycemic induced organ damaged [30].…”

Phytochemicals, Antioxidant, and Antidiabetic Effects of Ranunculus hirtellus Aerial Parts and Roots: Methanol and Aqueous Extracts

“…hirtellus suggest their potential in treating various ailments. These compounds have been reported in several studies from other medicinal plants. , …”

Assessment of Phytochemical Profiling and Therapeutic Potential of the Ethanolic Extract of Vitex negundo (L.)

“…Natural resources' unlimited application in treating various human ailments increases their usage due to their inexpensive cost and lack of adverse effects. The World Health Organisation reports that 80% of people in poor nations rely on traditional medicines are generally economical, safe, efficient, and reliable (Khan et al, 2023). Natural resources, such as plants, play a crucial role in screening for unique and effective solutions drug development aims to address high costs and drug resistance (Rahman et al, 2023).…”