Anti-hyperglycaemic effect and nutritional properties of an aqueous extract of Larrea divaricata Cav. (jarilla) in streptozotocin-induced diabetes in mice

Peralta, Ignacio; Marrassini, Carla; Martin, Malen Saint; Plantamura, Yanina Santander; Cogoi, Laura; Pellegrino, N; Alonso, María R.; Anesini, Claudia

doi:10.1016/j.jep.2022.115429

Cited by 2 publications

(2 citation statements)

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“…The crude ash was analyzed by the direct incineration method (JSMF‐140 T, JSR, Inc., Laboratory) at 600°C according to the American Association of Cereal Chemists (AACC) official methods (Boye et al, 2010 ). The crude protein was determined using a semi‐micro‐Kjeldahl method (Peralta et al, 2022 ) with a nitrogen factor of 6.25. The crude fat was determined using the Soxhlet extraction method (Peralta et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

“…The crude protein was determined using a semi‐micro‐Kjeldahl method (Peralta et al, 2022 ) with a nitrogen factor of 6.25. The crude fat was determined using the Soxhlet extraction method (Peralta et al, 2022 ). Total carbohydrate was calculated by subtracting the sum of the moisture, ash, crude protein, and crude lipid content from the total weight of the food.…”

Section: Methodsmentioning

confidence: 99%

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Gryllus bimaculatus‐containing diets protect against dexamethasone‐induced muscle atrophy, but not high‐fat diet‐induced obesity

Kim

et al. 2023

Food Science & Nutrition

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Sarcopenia and obesity are emerging as major social problems. In this study, we examined whether Gryllus bimaculatus (GB), an edible insect, prevents dexamethasone‐induced muscle atrophy (sarcopenia) or high‐fat diet (HFD)‐induced obesity in mice. We generated a standard chow diet (SCD) + GB (85% SCD and 15% GB powder) and HFD + GB (85% HFD and 15% GB powder). SCD + GB feeding increased gains in body weight and white adipose tissue (WAT). Despite no difference in weight change between HFD + GB‐ and HFD‐fed mice, HFD + GB feeding aggravated insulin resistance compared with HFD feeding. SCD + GB or HFD + GB feeding did not change most gene expressions in the liver and WAT but did increase MyHC1 expression in the muscle, meaning that GB increased muscle generation. Therefore, we fed SCD + GB with dexamethasone, which induces muscle degeneration. As a result, muscle fiber size increased, as did grip strength compared with dexamethasone‐injected mice. In addition, SCD + GB reduced the expression of muscle degradation factors, such as atrogin1 and muscle RING‐finger protein 1 (MuRF1). Furthermore, SCD + GB feeding increased Akt, mTOR, and p70S6K phosphorylation and MyHC1 expression, meaning that it may have increased protein synthesis. In conclusion, GB has great potential for inhibiting dexamethasone‐induced muscle mass loss by increasing muscle protein synthesis and inhibiting muscle protein degradation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%