2022
DOI: 10.1038/s41598-022-19947-2
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Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy imply MAPK pathway and calcium dynamics modulation

Abstract: Several recent studies have established the efficacy of photobiomodulation therapy (PBMT) in painful clinical conditions. Diabetic neuropathy (DN) can be related to activating mitogen-activated protein kinases (MAPK), such as p38, in the peripheral nerve. MAPK pathway is activated in response to extracellular stimuli, including interleukins TNF-α and IL-1β. We verified the pain relief potential of PBMT in streptozotocin (STZ)-induced diabetic neuropathic rats and its influence on the MAPK pathway regulation an… Show more

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Cited by 13 publications
(6 citation statements)
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“…A total of 23 studies were conducted, including 5 on preclinical models- ( 49 53 ) and 18 in humans ( 28 33 , 46 , 54 – 63 ) ( Table 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…A total of 23 studies were conducted, including 5 on preclinical models- ( 49 53 ) and 18 in humans ( 28 33 , 46 , 54 – 63 ) ( Table 2 ).…”
Section: Resultsmentioning
confidence: 99%
“…It can transduce extracellular stimuli into cells. Research has shown that it is related to mitochondrial failure caused by metabolic disorders ( 131 , 132 ).…”
Section: Mechanismmentioning
confidence: 99%
“…The oxidative stress and extracellular stimuli, such as Ca 2+ generated by upstream pathways, can stimulate the phosphorylation of MAPKs and activate the MAPK pathway. In addition to acting as a downstream pathway, hyperglycemia may directly cause phosphorylation of MAPKs ( Figure 3 ) ( 132 , 133 ). A study on peripheral neuropathy caused by paclitaxel showed that MAPK signaling pathways such as JNK, ERK1/2, and nuclear factors- κB played a major role in it ( 134 ).…”
Section: Mechanismmentioning
confidence: 99%
See 1 more Smart Citation
“…21 This plethora of biological activities results in numerous therapeutic benefits beyond application to brain disorders. In fact, different preclinical studies suggest the applicability of PBM-induced biological effects to wound healing, 22 muscle regeneration, [23][24][25] and neuropathic pain, 26,27 among others. PBM has also been used to treat acute stroke, traumatic brain injury, 28 and several neurological and affective disorders, including MDD.…”
Section: Light Interactions With Biological Tissues: a Basis For Phot...mentioning
confidence: 99%