Anti-hyperalgesic effects of intrathecally administered neuropeptide W-23, and neuropeptide B, in tests of inflammatory pain in rats

Yamamoto, Tatsuo; Saito, Osamu; Shono, Koyo; Tanabe, Serabi

doi:10.1016/j.brainres.2005.03.027

Cited by 38 publications

(23 citation statements)

References 14 publications

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“…injection of either NPW23 or NPB significantly suppressed the expression of Fos-like immunoreactivity of the L4–5 spinal dorsal horn induced by formalin injection into the paw. These data suggest that spinally applied NPW/B suppressed the input of nociceptive information to the spinal dorsal horn, producing an analgesic effect on inflammatory pain, but not mechanical or thermal pain (Yamamoto et al, 2005). …”

Section: Biological Activities Of Npb and Npwmentioning

confidence: 99%

“…Intrathecal (i.t.) injection of either NPW23 or NPB also decreased agitation behaviors induced by formalin injection into the paw and attenuated the level of mechanical allodynia (Yamamoto et al, 2005). The effects were not antagonized by naloxone, suggesting that this effect is not mediated through the opioid receptor system.…”

Section: Biological Activities Of Npb and Npwmentioning

confidence: 99%

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NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Sakurai¹

2013

Front. Endocrinol.

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Neuropeptide B/W receptor-1 (NPBWR1) and NPBWR2 had been known as orphan receptors GPR7 and 8, respectively. Endogenous peptide ligands of these receptors, neuropeptide B (NPB) and neuropeptide W (NPW), were identified in 2002 and 2003 (Fujii et al., 2002; Brezillon et al., 2003; Tanaka et al., 2003). These peptides have been implicated in regulation of feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. In addition, strong and discrete expression of their receptors in the extended amygdala and bed nucleus of the stria terminalis suggests a potential role in regulating stress responses, emotion, anxiety, and fear. Recent studies of NPB/NPW using both pharmacological and phenotypic analyses of genetically engineered mice as well as a human study support this hypothesis.

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Section: Biological Activities Of Npb and Npwmentioning

confidence: 99%

Section: Biological Activities Of Npb and Npwmentioning

confidence: 99%

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Sakurai¹

2013

Front. Endocrinol.

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“…Therefore, NPW is believed to play an important role in feeding and energy metabolism. In addition, several studies have indicated that NPW regulates neuroendocrine function, plays a role in the stress response, and modulates inflammatory pain (Baker et al, 2003;Niimi and Murao, 2005;Taylor et al, 2005;Yamamoto et al, 2005;N. Yu et al, 2007).…”

Section: Introductionmentioning

confidence: 94%

Cloning and distribution of neuropeptide W and its receptors in pigs

Fang

Zheng

et al. 2015

Research in Veterinary Science

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“…15 Although the precise mechanisms responsible for the analgesic effect elicited by NPW23 or NPB in the rat formalin and carrageenan tests are not known, these data suggested that both spinally-applied NPW23 and NPB suppressed the input of nociceptive information to the spinal dorsal horn and indicated a new potential therapeutic approach to treating inflammatory pain. 15 Interestingly, samples taken from patients with inflammatory/immunomediated neuropathies showed a higher expression of NPBWR1 restricted to myelin-forming Schwan cells where the receptor is constitutively present at low levels. Consistently, animal models of acute inflammatory and trauma-induced neuropathic pain exhibited an increased myelin-associated expression of NPBWR1, suggesting a therapeutic role of this receptor in analgesia and as a marker of inflammatory neuropathies.…”

mentioning

confidence: 99%

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Urbano

Guerrero

Zhao

et al. 2012

Bioorganic & Medicinal Chemistry Letters

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Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure–activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one lead molecule with submicromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders.

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Anti-hyperalgesic effects of intrathecally administered neuropeptide W-23, and neuropeptide B, in tests of inflammatory pain in rats

Cited by 38 publications

References 14 publications

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion

Cloning and distribution of neuropeptide W and its receptors in pigs

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

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