Anti-human cytomegalovirus activity and toxicity of sulfonated anthraquinones and anthraquinone derivatives

Barnard, Dale L.; Fairbairn, Daryl W.; O’Neill, Kim L.; Gage, T.L.; Sidwell, Robert W.

doi:10.1016/0166-3542(95)00057-7

Cited by 49 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anthraquinone derivatives show a wide array of pharmacological activities including laxative, 25,26 anticancer, [27][28][29][30] antiinflammatory, 31 antiarthritic, 32 antifungal, 33 antibacterial, 34 antiviral, 35 antiplatelet, [36][37][38] and neuroprotective effects. 39 In addition, they have shown potential for the treatment of malaria 40 and multiple sclerosis 41 ; and there is continued interest in the development of new anthraquinone derivatives displaying biological activities.…”

Section: Anthraquinones As Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Anthraquinones As Pharmacological Tools and Drugs

Malik

Müller

2016

Medicinal Research Reviews

337

211

View full text Add to dashboard Cite

Anthraquinones (9,10-dioxoanthracenes) constitute an important class of natural and synthetic compounds with a wide range of applications. Besides their utilization as colorants, anthraquinone derivatives have been used since centuries for medical applications, for example, as laxatives and antimicrobial and antiinflammatory agents. Current therapeutic indications include constipation, arthritis, multiple sclerosis, and cancer. Moreover, biologically active anthraquinones derived from Reactive Blue 2 have been utilized as valuable tool compounds for biochemical and pharmacological studies. They may serve as lead structures for the development of future drugs. However, the presence of the quinone moiety in the structure of anthraquinones raises safety concerns, and anthraquinone laxatives have therefore been under critical reassessment. This review article provides an overview of the chemistry, biology, and toxicology of anthraquinones focusing on their application as drugs.

show abstract

Section: Anthraquinones As Drugsmentioning

confidence: 99%

“…Barnard et al reported gentoxicity of RB-2 in the Comet test at a concentration of 30 μM. 35 In contrast, Venturini and Tamaro demonstrated that RB-2 was nonmutagenic in the Ames test at 100, 500, and 1000 μg/plate. AB-25 was also negative in this test at the same concentrations.…”

Section: Toxicity Of Reactive Blue 2 and Related Dyesmentioning

confidence: 99%

Anthraquinones As Pharmacological Tools and Drugs

Malik

Müller

2016

Medicinal Research Reviews

337

211

View full text Add to dashboard Cite

show abstract

“…In particular, they have been reported to (i) have anti-topoisomerase activity and induce telomerase expression [5,6,7]; (ii) be active ingredients of Chinese traditional medicine [8], and (iii) inhibit human cytomegalovirus [9,10], poliovirus [11] and hepatitis B viruses and HIV-1 [12,13] in cell-based assays [14,15], and inhibit HIV-1 RT [14,15,16,17,18] and integrase activities in biochemical assays [19]. In particular, various substituted AQs were first shown to inhibit the HIV-1 replication in lymphocytes and the HIV-1 RT in biochemical assays [17].…”

Section: Introductionmentioning

confidence: 99%

New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

et al. 2012

View full text Add to dashboard Cite

Background: The degradative activity of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), termed ribonuclease H (RNase H), which hydrolyzes the RNA component of the heteroduplex RNA:DNA replication intermediate, is an excellent target for drug discovery. Anthraquinones (AQs) and their derivatives, which are common secondary metabolites occurring in bacteria, fungi, lichens and a large number of families in higher plants, have been reported to have several biological activities including that of inhibiting HIV-1 RT activities in biochemical assays. Methods: We have assayed new AQ derivatives on HIV-1 RNase H activities in biochemical assays. Results: Six series of new AQ derivatives with various substituents at positions 1, 2, 3 and 4 of the AQ ring were tested, and new analogs able to inhibit HIV-1 RT-associated RNase H activity in the low micromolar range were found. Conclusions: Our results demonstrate that AQ derivatives are promising anti-RNase H inhibitors.

show abstract

“…Biologically active anthraquinone derivatives are found in bacteria, fungi, and insects, and are used in a variety of products such as textile dyes, paints, foods, cosmetics, and pharmaceuticals [8]. Furthermore, anthraquinone derivatives have various biological effects such as anti-cancer [9], anti-inflammatory [10], antibacterial [11], and antiviral effects [12]. Physcion is an anthraquinone derivative and has been shown to induce apoptosis of acute lymphoblastic leukemia [13], human nasopharyngeal carcinoma [14], human colorectal cancer (SW620 cells) [15], and hepatocellular carcinoma cells [16].…”

Section: Introductionmentioning

confidence: 99%

Physcion-Matured Dendritic Cells Induce the Differentiation of Th1 Cells

Hwang

Kim

Yee

2020

IJMS

View full text Add to dashboard Cite

In addition to their use as colorants, anthraquinone derivatives have numerous medical applications, for example, as antibacterial and antiinflammatory agents. We confirmed that physcion (an anthraquinone derivative) induces TNF-alpha production by macrophages and increased the expressions of surface molecules (CD40, CD80, and CD86) and major histocompatibility complex (MHC) II. Based on these results, we hypothesized that physcion might induce the maturation of dendritic cells (DCs) to antigen-presenting cells (APCs), and decided to conduct in vitro experiments using bone-marrow-derived DCs (BMDCs). Physcion was not toxic to DCs and increased the expression of surface molecules (e.g., CD40, CD80, CD86, and MHC II) and the production of cytokines (e.g., IL-12p70, IL-1beta, IL-6, and TNF-alpha), but not of IL-10. To confirm that DCs matured by physcion induce T-cell-immune responses, naive CD4+ T cells were treated with physcion-treated DCs or their supernatants. Physcion induced the maturation of DCs, which promoted the polarization of Th1 cells. Our results show physcion-induced DC maturation via TLR4, and that mature DCs promote the differentiation of Th1 cells without affecting the differentiation of Th2 cells. These findings show that physcion has potential use as a treatment for inflammatory diseases associated with Th1/Th2 cell imbalance.

show abstract

Anti-human cytomegalovirus activity and toxicity of sulfonated anthraquinones and anthraquinone derivatives

Cited by 49 publications

References 23 publications

Anthraquinones As Pharmacological Tools and Drugs

Anthraquinones As Pharmacological Tools and Drugs

New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

Physcion-Matured Dendritic Cells Induce the Differentiation of Th1 Cells

Contact Info

Product

Resources

About