Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives

Pharmacological activities of some new polycyclic triazolopyrazolopyridazine derivatives

“…In addition, we reported that certain of our newly substituted heterocyclic compounds exhibited antiparkinsonian [21], antitumor [22][23][24], antimicrobial [25] and anti-inflammatory [26] activities. Recently, some new substituted heterocyclic derivatives have been synthesized [27], which exhibit antimicrobial [28,29], analgesic, antiinflammatory and activities [30][31][32][33][34][35]. In view of these observations and as continuation of our previous works in heterocyclic chemistry, we have herein synthesized some new poly heterocyclic fused ring systems containing pyrazole nuclei, and tested their antiinflammatory, analgesic and antimicrobial activities in comparison to indonethacin, valdoxib, tertacycline, ketoconazole, bleomycin, gallic acid as positive controls.…”

An Efficient Synthesis of Benzothieno-[3',2': 2,3]pyrido[4,5-d]thiazolo[3,2-a]pyrimidin-5-ones

“…其 中, 含有噻唑并嘧啶骨架结构的噻唑并[3,2-a]嘧啶类化 合物由于其结构的多样性及表现出的多种生物活性和 药理活性, 如抗癌 [2] 、抗炎 [3] 、抗病毒 [4] 、镇痛 [5] 等, 近 年来引起极大的关注 [6] .…”

Synthesis, QSAR and docking studies of 5HT2A receptor antagonising thiazolo[3,2-a]pyrimidines as antipsychotic agents

“…Thiazolo[3,2-a]pyrimidine and its derivatives are known to possess diverse biological activities such as antimicrobial (5), anti-inflammatory (6), antiviral (7), calcium antagonists (8) and antitumor (9). Recently it has been reported that thiazolo [3,2-a]pyrimidine possess selective 5HT 2A receptor antagonistic activity (10) and it possess high affinity for 5HT 2A receptor.…”