Anti-HIV Prenylated Flavonoids from Monotes africanus

Abstract

Six flavonoids, among them a new dihydroflavonol, 6,8-diprenylaromadendrin (1), and the flavonol 6,8-diprenylkaempferol (3), have been isolated from the organic extract of Monotes africanus. The isolated compounds containing a 5,7-dihydroxy-6,8-diprenyl system in the A ring of the flavonoid (1, 3, and 6) exhibited HIV-inhibitory activity in the XTT-based, whole-cell screen. In addition, several (13)C NMR assignments of lonchocarpol A (6) were corrected.

Woody species from the Mozambican Miombo woodlands: A review on their ethnomedicinal uses and pharmacological potential

“…However, some studies were carried out concerning the potential medicinal properties of this species. Meragelman et al (2001) isolated flavonoids exhibiting HIV-inhibitory activity from leaf extracts of M. engleri and antifungal activity against Candida albicans was reported by Kenez et al (2008). (Chirisa and Mukanganyama, 2016).…”

“…M. engleri, B. abyssinica and P. angolensis (anti-viral) (Asres et al, 2001;Meragelman et al, 2001;Mulaudzi et al, 2013);A. senegalensis, C. zeyheri, T. stenostachya and C. spinosa (anti-tumoral) (Ahmed et al, 2010;Fyhrquist et al, 2006;Gao et al, 2010;Nibret et al, 2010); Burkea africana (glaucoma) (Dzoyem and Eloff, 2015).…”

Strategies for the Preparation of Differentially Protectedortho-Prenylated Phenols

“…Special Notes (1)(2)(3)(4)(5)(6) 6, 148.5, 144.9, 122.6, 122.1, 120.3, 117.4, 98.6, 83.5, 35.1, 32.4, 32.9, 24.3, 24.0. 3, 142.2, 135.3, 127.6, 122.0, 121.7, 120.8, 113.5, 94.6, 27.9, 26.0, 18.1.…”

Luteolin as a potent anti-leishmanial agent against intracellular Leishmania tropica parasite

“…Flavonoids and alkylphenones possess a variety of biological and pharmacological activities, including antioxidant [7], antibacterial, antiulcer [8], antifungal [9], antiviral [10], HIV -inhibiting [11], and anti-herpes simplex type 1 (HSV-1) [12]. They also inhibit electron transfer in mitochondrial inner membrane [13].…”

“…Flavonoids and alkylphenones are chemically well investigated, and a large number of member compounds have been reported. These include flavonoids and luteolin [14]; luteolin-4'-O-β-Dglucopyranoside [15]; apigenin 4-O-β-Dglucopyranoside [16]; apigenin [15]; xanhoangelol [8]; macaranggin [7]; artelastin [10]; 5,7-Dihydroxy-6,8-diphenyl flavonoids [11]; leachianone G [12] and alkylphenones such as Lalioside [17], 2,4,6-trihydroxyacetophenone-2-O-β-D-glucopyranoside [18] and lawsoniaside [19]. However, the current work deals with antileishmanial and cytotoxic effects of naturally occurring plant phenolic compounds having four flavonoids and one alkylphenone.…”