Anti-HIV Effect of Liposomes Bearing CXCR4 Receptor Antagonist N15P

Yu-hong, Zhao; Sun, Han; Li, Xiuying; Mo, Xuemei; Guang, Zhang

doi:10.4314/tjpr.v12i4.9

Cited by 1 publication

(1 citation statement)

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“…It was found that DV1 and DV3 exhibited moderate affinity while DV1-K-(DV3) displayed high affinity towards CXCR4 and hence can be explored further for targeting CXCR4 positive cells. In a recent study, a peptide N15P derived from the amino acid sequence 1-15 of the N-terminus of the viral macrophage inflammatory protein (vMIP-II) was encapsulated in a nanoliposomal carrier [76]. This liposomal system was found to inhibit the SDF-1 induced chemotactic activity of peripheral blood mononuclear cells through competitive binding to CXCR4.…”

Section: Chemokine Receptorsmentioning

confidence: 99%

Targeting strategies for delivery of anti-HIV drugs

Ramana

Anand

Sethuraman

et al. 2014

Journal of Controlled Release

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Human Immunodeficiency Virus (HIV) infection remains a significant cause of mortality globally. Though antiretroviral therapy has significantly reduced AIDS-related morbidity and mortality, there are several drawbacks in the current therapy, including toxicity, drug-drug interactions, development of drug resistance, necessity for long-term drug therapy, poor bio-availability and lack of access to tissues and reservoirs. To circumvent these problems, recent anti-HIV therapeutic research has focused on improving drug delivery systems through drug delivery targeted specifically to host cells infected with HIV or could potentially get infected with HIV. In this regard, several surface molecules of both viral and host cell origin have been described in recent years, that would enable targeted drug delivery in HIV infection. In the present review, we provide a comprehensive overview of the need for novel drug delivery systems, and the successes and challenges in the identification of novel viral and host-cell molecules for the targeted drug delivery of anti-HIV drugs. Such targeted anti-retroviral drug delivery approaches could pave the way for effective treatment and eradication of HIV from the body.

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Section: Chemokine Receptorsmentioning

confidence: 99%