Anti-HIV activity of Indian medicinal plants

Sabde, Sudeep; Bodiwala, Hardik S.; Karmase, Aniket; Deshpande, Preeti J.; Kaur, Amandeep; Ahemad, Nafees; Chauthe, Siddheshwar Kisan; Brahmbhatt, Keyur G.; Phadke, Rasika U.; Mitra, Debashis; Bhutani, K. K.; Singh, Inder Pal

doi:10.1007/s11418-011-0513-2

Cited by 64 publications

(39 citation statements)

References 30 publications

(46 reference statements)

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“…The results revealed that oleandrin reduced the amount of envelope proteins of virus whereas AZT inhibited viral replication in infected cells by reducing RT activity. In another systematic study, moderate anti‐HIV‐1 activity (40%‐60% inhibition) of alkaloid‐rich extracts of Catharanthus roseus and Alstonia scholaris leaves, as well as from Rauvolfia serpentina roots, was reported (Sabde et al, ). Betulinic acid (Moghaddam, Ahmad, & Samzadeh‐Kermani, ) and ellagic acid (Narayan & Rai, ) from different plant sources were reported for their anti‐HIV potential.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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“…Many of these possess antimicrobial activity against many classes of bacteria, virus, insects and many other harmful organisms [38]. In 2011, Indian medicinal plants have been detected with potential activity against HIV [80]. So, Botanicals show promising future towards treating some of fatal diseases in the world and list of antimicrobials incorporated directly into polymers used for food packaging tabulated in Table 1.…”

Section: Introductionmentioning

confidence: 99%

A Relook at Food Packaging for Cost Effective by Incorporation of Novel Technologies

Ananda

Manukumar

Umesha

et al. 2017

J Package Technol Res

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Food packaging is one of the essential subject areas in food technology that play an important role in preserving all types of foods. Due to many disadvantages like a non-biodegradable and environmental problem in food packaging industry, a newer concept of use of biodegradable materials in food packaging from botanicals created tremendous innovative ideas in food packaging from past few years. An increased interest in hygiene in everyday life as well as in food, feed, and medical issues lead to a strong interest in films and blends to prevent the growth and accumulation of harmful bacteria. A growing trend is to use synthetic and natural antimicrobial polymers, to provide non-migratory and non-depleting protection agents for application in films, coatings, and packaging. The aim of this review was to offer a complete view of the state of the art on natural biodegradable polymer packages for food application compared to synthetics. Also, heightened overall developments in botanicals, natural and synthetic biopolymers in food packaging and its applications were described by focusing future improvements. This is a timely review as there has been a recent renewed interest in research studies, both in the industry and academia, towards the development of a new generation of biopolymer-based food packaging materials with possible applications in other areas. A lot of achievements in nanotechnology compared to synthetic materials attracted food industry for its wonderful applications in packaging was highlighted.

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“…Various natural products such as flavonoids and alkaloids have been reported to inhibit HIV-1 RT activity [3][4][5][6]. The concentrations of such substances required for 50 % effective inhibition (IC 50 ) of the activity of the DNA polymerase were reported to be on the order of several tens to several hundreds of lM.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components

et al. 2015

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Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported that ethanol and water extracts of Brasenia schreberi (Junsai) inhibited the DNA polymerase activity of HIV-1 RT [Hisayoshi et al. (2014) J Biol Macromol 14:59-65]. In this study, we screened 43 edible plants and found that ethanol and water extracts of Brasenia schreberi and water extract of Petasites japonicus strongly inhibit not only the activity of DNA polymerase to incorporate dTTP into poly(rA)-p(dT)15 but also the activity of RNase H to hydrolyze the RNA strand of an RNA/DNA hybrid. In addition, these three extracts inhibit HIV-1 replication in human cells, with EC50 values of 1-2 µg/ml. These results suggest that Brasenia schreberi and Petasites japonicus contain substances that block HIV-1 replication by inhibiting the DNA polymerase activity and/or RNase H activity of HIV-1 RT.

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Anti-HIV activity of Indian medicinal plants

Cited by 64 publications

References 30 publications

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

A Relook at Food Packaging for Cost Effective by Incorporation of Novel Technologies

Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components

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