Anti-HIV Activity and Immunomodulatory Properties of Fractionated Crude Extracts of Alternaria alternata
Mbali X. Kubheka,
Sizwe I. Ndlovu,
Nompumelelo P. Mkhwanazi
Abstract:Developing new anti-human immunodeficiency virus (HIV) drug candidates that target different sites in HIV-1 replication, with better resistance profiles and lower drug toxicity, is essential to eradicating HIV. This study investigated the potential of fractionated crude extracts of Alternaria alternata as immunomodulatory or anti-HIV drug candidates. Solid-phase extraction (SPE) was used to fractionate A. alternata PO4PR2 using three different columns: MAX (Mixed-mode, strong Anion-eXchange), MCX (Mixed-mode, … Show more
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