Anti-HIV-1 integrase effect of compounds from<i>Aglaia andamanica</i>leaves and molecular docking study with acute toxicity test in mice

Puripattanavong, Jindaporn; Tungcharoen, Pattreeya; Chaniad, Prapaporn; Pianwanit, Somsak; Tewtrakul, Supinya

doi:10.3109/13880209.2015.1071413

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The active compound, N -methyl-trans-4-hydroxy-L-proline was isolated from Aglaia andamanica leaves. It has been reported to be potent anti-HIV-1 agents with an IC 50 value of 11.8 μ g/mL [46]. In addition, bisdemethoxycurcumin from the rhizomes of Boesenbergia kingii showed moderate anti-HIV-1 IN with an IC 50 value of 47.7 μ M [47].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Chaniad

Sudsai

Septama

et al. 2019

Advances in Pharmacological Sciences

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Betula alnoides is a medicinal plant in Thai traditional longevity preparations. The crude extracts of this plant possess various biological activities. However, the isolated compounds from this plant have no reports of anti-HIV-1 integrase (IN) activity. Therefore, the present study aims to investigate the anti-HIV-1 integrase and anti-inflammatory effects of isolated compounds from this plant and predict the interaction of compounds with integrase active sites. From the bioassay-guided fractionation of the ethanol extract of B. alnoides stems using chromatographic techniques, five pentacyclic triterpenoid compounds were obtained. They are betulinic acid (1), betulin (2), lupeol (3), oleanolic acid (4), and ursolic acid (5). Compound 2 exhibited the most potent inhibitory activity against HIV-1 IN, with an IC50 value of 17.7 μM. Potential interactions of compounds with IN active sites were investigated using computational docking. The results indicated that active compounds interacted with Asp64, a residue participating in 3′-processing, and Thr66, His67, and Lys159, residues participating in strand-transfer reactions of the integration process. Regarding anti-inflammatory activity, all compounds exerted significant inhibitory effects on LPS-induced nitric oxide production (IC50 < 68.7 μM). Thus, this research provides additional scientific support for the use of B. alnoides in traditional medicine for the treatment of HIV patients.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Chaniad

Sudsai

Septama

et al. 2019

Advances in Pharmacological Sciences

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“…The acute toxicity of compound A26 in mice was tested by modified Kou's method 46,47 . The dose range of compound A26 on 100% death and 0% death of experimental mice was determined through pre‐experiment, and the interval between the dose groups was determined to be 1.3.…”

Section: Methodsmentioning

confidence: 99%

“…The acute toxicity of compound A26 in mice was tested by modified Kou's method. 46,47 The dose range of compound A26 on 100% death and 0% death of experimental mice was determined through pre-experiment, and the interval between the dose groups was determined to be 1.3. In the formal experiment, 30 female mice weighing 18-22 g were randomly divided into five groups with six mice in each group.…”

Section: Acute Toxicity Testmentioning

confidence: 99%

Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino‐Aldehyde condensation strategy

Ma,

Zhou,

Wang

et al. 2023

Pest Management Science

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BackgroundChemical fungicides are the mainstay of plant disease control in agricultural production, but there are a very limited number of drugs that can effectively control plant diseases. Two series of secondary amine derivatives were synthesized using the diamine skeleton combined with saturated aromatic and aliphatic aldehydes, and their antibacterial and antifungal activities against plant pathogens were determined. In addition, the antimicrobial mechanism of the highly active compound A26 was preliminarily examined against Xanthomonas oryzae (Xoo).ResultsCompound A26 exhibited the highest antibacterial potency among all the target compounds, with MIC values of 3.12, 3.12, and 12.5 μg/mL against Xoo, Xanthomonas axonopodis pv. Citri (Xac) and Pseudomonas sollamacearum (Ps), respectively. In addition, compound A26 had powerful curative and protective effects against Xoo at 200 μg/mL, and was better than the control agent Xinjunan. Preliminary mechanistic studies showed that compound A26 reduced the bacterial pathogenicity by targeting cell membranes and inhibiting the secretion of extracellular polysaccharides (EPS). Meanwhile, the toxicity of compound A26 to Human Embryonic Kidney 293 cells and Human Liver‐7702 was similar to that of Xinjunan, and it had the moderate toxicity according to the World Health Organization classification standard of oral exogenous toxicity with the LD50 of 245.47 mg/kg.ConclusionSecondary amines have efficient and broad‐spectrum antibacterial activity against plant pathogenic bacteria and are expected to be a new class of candidate compounds for antibacterial drugs.This article is protected by copyright. All rights reserved.

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A search for potential anti-HIV phytoconstituents from the natural product repository

Pathak

Sagar

Bhatt

et al. 2022

ADV TRADIT MED (ADTM)

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Anti-HIV-1 integrase effect of compounds fromAglaia andamanicaleaves and molecular docking study with acute toxicity test in mice

Abstract: Context: Acquired immunodeficiency syndrome (AIDS) is a serious health problem worldwide.

Cited by 5 publications

References 16 publications

Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham

Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino‐Aldehyde condensation strategy

A search for potential anti-HIV phytoconstituents from the natural product repository

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