Anti-HIV-1 integrase activity of<i>Mimusops elengi</i>leaf extracts

Suedee, Areerat; Tewtrakul, Supinya; Panichayupakaranant, Pharkphoom

doi:10.3109/13880209.2013.810649

Cited by 25 publications

(11 citation statements)

References 21 publications

(22 reference statements)

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“…In this regard, Sanguisorba officinalis [11] and Pelargonium sidoides [12] extracts inhibited the entry of the virus into the cells. Pometia pinnata [13] and Mimusops elengi [14] leaf extracts can modulate the activity of HIV integrase, and numerous vegetable extracts showed inhibitory potential on reverse transcriptase. [15] [16] In addition to crude extracts, essential oil (EO) isolated from aromatic plants by steam or hydro-distillation showed specific antiviral activity.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oils from Thymus vulgaris, Cymbopogon citratus, and Rosmarinus officinalis, and Their Effects on the HIV‐1 Tat Protein Function

Feriotto

Marchetti

Costa

et al. 2018

Chemistry & Biodiversity

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New drugs would be beneficial to fight resistant HIV strains, in particular those capable of interfering with essential viral functions other than those targeted by highly active antiretroviral therapy drugs. Despite the central role played by Tat protein in HIV transcription, a search for vegetable extracts able to hamper this important viral function was never carried out. In this work, we evaluated the chemical composition and possible interference of essential oil from Thymus vulgaris, Cananga odorata, Cymbopogon citratus, and Rosmarinus officinalis with the Tat/TAR-RNA interaction and with Tat-induced HIV-1 LTR transcription. GC/MS Analysis demonstrated the biodiversity of herbal species translated into essential oils composed of different blends of terpenes. In all of them, 4 - 6 constituents represent from 81.63% to 95.19% of the total terpenes. Essential oils of Thymus vulgaris, Cymbopogon citratus, and Rosmarinus officinalis were active in interfering with Tat functions, encouraging further studies to identify single terpenes responsible for the antiviral activity. In view of the quite different composition of these essential oils, we concluded that their interference on Tat function depends on specific terpene or a characteristic blend.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition of Essential Oils from Thymus vulgaris, Cymbopogon citratus, and Rosmarinus officinalis, and Their Effects on the HIV‐1 Tat Protein Function

Feriotto

Marchetti

Costa

et al. 2018

Chemistry & Biodiversity

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“…Medicinal plants with anti‐HIV‐1 activity have been studied intensively (Cheenpracha, Karalai, Ponglimanont, Subhadhirasakul, & Tewtrakul, ; Suedee, Tewtrakul, & Panichayupakaranant, ; Tewtrakul, Itharat, & Rattanasuwan, ; Wang et al., ). Ellagic acid is a naturally occurring polyphenol compound found in pomegranates, blackberries, raspberries, strawberries, and walnuts (Cerda, Tomas‐Barberan, & Espin, ; Vattem & Shetty, ).…”

Section: Introductionmentioning

confidence: 99%

Ellagic acid inhibits HIV‐1 infection in vitro: Potential role as a novel microbicide

et al. 2018

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“…Catechins isolated from green tea also had antiviral activity on influenza virus (Song et al, 2005) and epigallocatechin gallate was found to inhibit HIV-1 replication by blocking gp120-CD4 interaction (Nance et al, 2009). It has been reported that the mixture of gallocatechin and epigallocatechin isolated from Mimusops elengi leaf extract possess good anti-HIV-1 IN effect (Suedee et al, 2014). Protocatechuic acid has been shown to have antiinflammatory and analgesic properties in rats and mice (Lende et al, 2011).…”

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confidence: 99%

Anti-HIV-1 integrase activity and molecular docking of compounds fromAlbizia procerabark

Panthong

Bunluepuech

Boonnak

et al. 2015

Pharmaceutical Biology

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Context: Albizia procera (Roxb.) Benth. (Mimosaceae) has been traditionally used in Thai longevity preparations. Thus, searching for HIV-1 integrase (HIV-1 IN) agents from natural sources is of interest. Objective: The objective of this study is to examine the inhibitory activity against HIV-1 IN of compounds isolated from the stem bark of Albizia procera. Materials and methods: The EtOH extract and isolated compounds of Albizia procera bark were examined for anti-HIV-1 IN activity at various concentrations (10-100 mg/mL and 10-100 mM) using the multiplate integration assay and molecular docking. Results and discussions:The results showed that the ethanol extract had good anti-HIV-1 IN activity with an IC 50 value of 19.5 mg/mL, whereas ethyl acetate fraction exhibited the most potent with an IC 50 value of 19.1 mg/mL, followed by water fraction (IC 50 value ¼ 21.3 mg/mL), hexane and chloroform fractions (IC 50 value4100 mg/mL), respectively. From bioassay-guided isolation, the ethyl acetate fraction was further separated to give two compounds which are (+)-catechin (1) and protocatechuic acid (2), respectively. Of the tested samples, (+)-catechin (1) exhibited appreciable activity against HIV-1 IN with an IC 50 value of 46.3 mM, whereas protocatechuic acid (2) showed mild activity with 46.0% inhibition at concentration of 100 mM. (+)-Catechin (1) could interact with Thr66, Gly148, and Glu152 in the core domain of IN enzyme, whereas protocatechuic acid (2) could bind with Thr66, His67, Glu152, Asn155, and Lys159. This is the first report on anti-HIV-1 IN activity of Albizia procera bark. These results may suggest that Albizia procera bark has potential as anti-HIV-1 IN agent.

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Anti-HIV-1 integrase activity ofMimusops elengileaf extracts

Cited by 25 publications

References 21 publications

Chemical Composition of Essential Oils from Thymus vulgaris, Cymbopogon citratus, and Rosmarinus officinalis, and Their Effects on the HIV‐1 Tat Protein Function

Chemical Composition of Essential Oils from Thymus vulgaris, Cymbopogon citratus, and Rosmarinus officinalis, and Their Effects on the HIV‐1 Tat Protein Function

Ellagic acid inhibits HIV‐1 infection in vitro: Potential role as a novel microbicide

Anti-HIV-1 integrase activity and molecular docking of compounds fromAlbizia procerabark

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