Anti-HIV-1 Activity of Herbs in Labiatae.

Yamasaki, Katsuhiro; Nakano, Masami; Kawahata, Takuya; Mori, Haruyo; Otake, Toru; Ueda, Noboru; Oishi, Isao; Inami, Rie; Yamane, Megumi; Nakamura, Miki; Murata, Hiroko; Nakanishi, Teruyuki

doi:10.1248/bpb.21.829

Cited by 215 publications

(125 citation statements)

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“…Moreover, enveloped viruses distinct to flavivirus were also inactivated by treatment with the essential oil obtained from medicinal plants. The in vitro replication abilities of the herpes simplex virus, hepatitis B virus and human immunodeficiency virus were suppressed by the previous exposure to essential oils but not by treatment of the cell with the essential oil before the adsorption of the virus (Zhang et al 1988, siddiqui et al 1996, Yamasaki et al 1998, schuhmacher et al 2003, saddi et al 2007, Koch et al 2008.…”

Section: Resultsmentioning

confidence: 99%

“…There is evidence that shows that essential oils from various herb species can directly inactivate the virus. Inhibition of enveloped virus subsequent replication in vitro (herpes simplex virus, hepatitis B virus and human immunodeficiency virus) is observed by incubation of the virus with essential oil before cell adsorption (Yamasaki et al 1998, Zhang et al 1998, saddi et al 2007). …”

Section: No Viral Inhibitory Effect Was Observed By Addition Of the Ementioning

confidence: 99%

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Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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The inhibitory effect of Lippia alba and Lippia citriodora essential oils on dengue virus serotypes replication in vitro was investigated. The cytotoxicity (CC 50 ) was evaluated by the MTT assay and the mode of viral inhibitory effect was investigated with a plaque reduction assay. The virus was treated with the essential oil for 2 h at 37 o C before cell adsorption and experiments were conducted to evaluate inhibition of untreated-virus replication in the presence of oil. Antiviral activity was defined as the concentration of essential oil that caused 50% reduction of the virus plaque number (IC 50 ). L. alba oil resulted in less cytotoxicity than L. citriodora oil (CC 50 : 139.5 vs. 57.6 µg/mL). Virus plaque reduction for all four dengue serotypes was observed by treatment of the virus before adsorption on cell. The IC 50 values for L. alba oil were between 0. 4-32.6 µg/mL and between 1.9-33.7 µg/mL for L. citriodora oil. No viral inhibitory effect was observed by addition of the essential oil after virus adsorption. The inhibitory effect of the essential oil seems to cause direct virus inactivation before adsorption on host cell.Key words: essential oil -antiviral -virucidal activity -dengue virus -Lippia sp.Dengue is an acute illness characterised by the hemorrhagic fever caused by dengue virus (DENV) that is transmitted to humans by Aedes mosquitoes. DENV infection results in a spectrum of disease ranging from a mild febrile illness or dengue fever to a severe disease or dengue hemorrhagic fever/dengue shock syndrome. Among the human arboviral diseases, dengue is responsible for causing most illness and death. It has been estimated that 50-100 million dengue infections occur each year in tropical urban areas around the world with 20,000-25,000 deaths (Gubler 2006).DENV is a member of the Flaviviridae family and it exists as four related serotypes (DENV-1 2, 3 and 4). The virus possesses an icosahedral nucleocapsid core surrounded by a host-derived lipid membrane (envelope), in which the envelope (E) protein and membrane (M) protein are embedded. The Flavivirus enters into the host cell by receptor-mediated endocytosis into coated vesicles, a process in which the E protein plays the major role. The E protein mediates interactions within the virus and the components of the host cell membrane involved in virus adsorption and the E protein interacts with the membrane cell during fusion (Lindenbach & Rice 2007). Compounds that interact with sites on the E protein that binds to structures on the cellular membrane affect the adsorption and fusion process. That interferes There is no antiviral drug for treatment for any of the Flavivirus and an effective vaccine for human use is not yet available to prevent dengue. Consequently, the development of antiviral drugs licensed for treatment of patients remains an urgent need to prevent dengue fatalities. Compounds obtained from traditional medicinal plants and herbs species have been reported to have antiviral activity and a wide variety of active phytochemicals hav...

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Section: Resultsmentioning

confidence: 99%

Section: No Viral Inhibitory Effect Was Observed By Addition Of the Ementioning

confidence: 99%

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Ocazionez

Meneses

Torres

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…have antiinflammatory (Hajhashemi et al, 2002), antispasmodic, antidiarrhea (Hajhashemi et al, 2000), and antioxidant (Abdollahi et al, 2003) effects in mammals, as well as antiviral (Yamasaki et al, 1998), antibacterial, and antifungal (Skocibusić and Bezić, 2004) effects, mainly in vitro.…”

Section: Introductionmentioning

confidence: 99%

The effect of savory (<i>Satureja khuzistanica</i>) essential oils on performance, liver and kidney functions in broiler chickens

Khosravinia¹,

Ghasemi²,

Alavi³

2013

J. Anim. Feed Sci.

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“…(Dhar et al 1968), and vitamins C, A, and minerals like calcium, zinc, and iron (Anbarasu & Vijayalakshmi 2007), as well as chlorophyll and many other phytonutrients. Recent interest in Ocimum has resulted from its inhibitory activity against HIV-I reverse transcriptase and platelets aggregation induced by collagen and ADP (adenosine 5'-disphosphate) (Okazaki et al 1998;Yamasaki et al 1998). However, the antimicrobial activity of Ocimum essential oil against microorganisms has been investigated by some researchers (Prasad et al 1986;Nakamura et al 1999;Adebolu & Oladimeji 2005;Adigüzel et al 2005;Moghaddam et al 2011; using different techniques and their investigations mostly covered one individual or two species.…”

mentioning

confidence: 99%

Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria

Saha¹,

Dhar²,

Sengupta³

et al. 2013

Czech J. Food Sci.

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Saha S., Dhar T.N., Sengupta C., Ghosh P.D. (2013): Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria. Czech J. Food Sci., 31: 194-202.The essential oils and methanol extracts of Ocimum basilicum L., Ocimum kilimandscharicum Guerke, Ocimum gratissimum L, Ocimum canum Sims, and Ocimum tenuiflorum L. (green type) were examined for their potential antibacterial activities. The chemical composition of essential oils of Ocimum species was analysed by GC-MS. The inhibitory effects of essential oils and methanol extracts were studied on two Gram-positive (Bacillus subtilis, Micrococcus luteus) and five Gram-negative (pseudomonas aeruginosa, Shigella dysenteriae, escherichia coli, Vibrio cholera, and Shigella flexneri) bacteria using disc-diffusion method. Minimum inhibitory concentration (MIC) was assessed by micro broth dilution method. The antibacterial test results showed that the essential oils of Ocimum basilicum L., Ocimum kilimandscharicum Guerke, and Ocimum gratissimum L. strongly inhibited the growth of all of the microorganisms studied, especially of the Gram-negative strains, whereas other two essential oils showed moderate activities. The result may suggest that the essential oils of Ocimum possess compounds with antibacterial activities, and therefore could be used as natural preservative ingredients in food and/or pharmaceutical industries.

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Anti-HIV-1 Activity of Herbs in Labiatae.

Cited by 215 publications

References 0 publications

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro

The effect of savory (<i>Satureja khuzistanica</i>) essential oils on performance, liver and kidney functions in broiler chickens

Biological activities of essential oils and methanol extracts of five Ocimum species against pathogenic bacteria

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