Anti-HIV-1 Activity of Ellagic acid Isolated from Terminalia paniculata

L, Chaitra Narayan; Rai, Ravishankar

doi:10.5530/fra.2016.1.12

Cited by 6 publications

(2 citation statements)

References 24 publications

(21 reference statements)

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“…Gallic acid, ellagic acid, myricetin, and isoquercitrin were the principal components in barks, flowers, inner skins, and leaves of C. crenata . Structurally, ellagic acid includes four hydroxyl groups bonded to the aromatic ring, which is the most important factor associated with strong DPPH scavenging activity [ 32 ]. Previously, ellagic acid was referred to inhibit lipid peroxidation, and it also possessed much stronger radical scavenging activity than dl-α-tocopherol [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

et al. 2017

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In this study, different plant parts (barks, flowers, inner skins, kernels and leaves) of Castanea crenata (Japanese chestnut) were analyzed for total phenolic, flavonoid, and tannin contents. Antioxidant properties were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), reducing power, and β-carotene bleaching methods. The highest total phenolic and tannin contents were found in the inner skins (1034 ± 7.21 mg gallic acid equivalent/g extract and 253.89 ± 5.59 mg catechin equivalent/g extract, respectively). The maximum total flavonoid content was observed in the flowers (147.41 ± 1.61 mg rutin equivalent/g extract). The inner skins showed the strongest antioxidant activities in all evaluated assays. Thirteen phenolic acids and eight flavonoids were detected and quantified for the first time. Major phenolic acids were gallic, ellagic, sinapic, and p-coumaric acids, while the principal flavonoids were myricetin and isoquercitrin. The inner skin extract was further fractionated by column chromatography to yield four fractions, of which fraction F3 exhibited the most remarkable DPPH scavenging capacity. These results suggest that C. crenata provides promising antioxidant capacities, and is a potential natural preservative agent in food and pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

et al. 2017

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“…In another systematic study, moderate anti‐HIV‐1 activity (40%‐60% inhibition) of alkaloid‐rich extracts of Catharanthus roseus and Alstonia scholaris leaves, as well as from Rauvolfia serpentina roots, was reported (Sabde et al, ). Betulinic acid (Moghaddam, Ahmad, & Samzadeh‐Kermani, ) and ellagic acid (Narayan & Rai, ) from different plant sources were reported for their anti‐HIV potential. The other members of family Apocynaceae such as Carissa carandas , Nerium oleander , Holarrhena antidysenterica , and Tabernaemontana divaricata are known to contain betulinic acid and ellagic acid as a major phytoconstituents.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Occurrence, types, properties and interactions of phenolic compounds with other food constituents in oil-bearing plants

Alu’datt

Rababah

Alhamad

et al. 2017

Critical Reviews in Food Science and Nutrition

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Phenolic phytochemicals have become of interest due to their therapeutic potential, particularly with regards to their anti-cancer, anti-inflammatory, hypolipidemic, and hypoglycemic properties. An evolving area of research involving phenolics in foods and their products pertains to the functional, biological, and nutritional consequences resulting from the binding between certain phenolic compounds and the macronutrient and micronutrient constituents of foods. The goal of this review is to provide a summary of studies investigating endogenous phenolic interactions with major components in food systems, including carbohydrates, proteins, lipids, minerals and vitamins, with a focus on the phenolic compounds and nutrients in oil-bearing plants. Another major objective is to provide a comprehensive overview of the chemical nature of phenolic interactions with food constituents that could affect the quality, nutritional and functional properties of foods. Such information can assist in the discovery and optimization of specific phenolic complexes in plant-based foods that could be utilized towards various applications in the food, nutraceutical and pharmaceutical industries.

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Anti-HIV-1 Activity of Ellagic acid Isolated from Terminalia paniculata

Cited by 6 publications

References 24 publications

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

Phenolic Compositions and Antioxidant Properties in Bark, Flower, Inner Skin, Kernel and Leaf Extracts of Castanea crenata Sieb. et Zucc

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Occurrence, types, properties and interactions of phenolic compounds with other food constituents in oil-bearing plants

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