Anti-HIV-1 Activities and Pharmacokinetics of New Arylpiperazinyl Fluoroquinolones

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

“…[1] Aryl difluoromethyl ethers are found in medicinally important compounds that include enzyme inhibitors, [2] anti-HIV agents [3] and atimicrobial agents. [4] Pantoprazole (Protonix®), a proton-pump inhibitor, is among the top 100 pharmaceuticals and contains a difluoromethyl ether.…”

Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana

“…[51][52][53] A investigação da coordenação das quinolonas aos íons metá-licos tem sido objeto de inúmeros trabalhos, envolvendo diversos aspectos que vão desde o entendimento das estruturas químicas, a participação de íons metálicos no seu modo de ação, além de estudos das propriedades biológicas apresentadas pelos complexos metálicos. 54,55 Alguns trabalhos apontam que o íon Mg(II) pode estar envolvido no modo de ação das fluorquinolonas, tendo importante papel na ligação destas substâncias ao complexo DNA-girase.…”

Synthesis and antibacterial properties of new N4-acetylated hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids

“…[1][2][3][4][5] Some derivatives such as 7-(4-arylpiperazin-1-yl)-6-fluoro-8-trifluoromethylquinolones, for example 1b, were reported to act as non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 reverse transcriptase. [6][7][8][9] 1a (R 1 = c-C 3 H 5 ; R 2 On the other hand, simple or heterocyclic-fused quinoxalinones have become interesting compounds for study as antiviral agents [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] exemplified by the 3,4-dihydroquinoxalin-2-one core (2, Y=O), a second generation of NNRTIs, that is opaviraline (2a) [22][23][24][25][26][27] and the related 2-thione talveraline (2b), [14][15][16][17][18][19] are in clinical development. …”