Anti-herpes Virus Activity of Fabaceous Triterpenoidal Saponins.

Kinjo, Junei; Yokomizo, Kazumi; Hirakawa, Tomoki; Shii, Yuichi; Nohara, Toshihiro; Uyeda, Masaru

doi:10.1248/bpb.23.887

Cited by 35 publications

(24 citation statements)

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“…In vitro screening has shown that some traditional medicinal herbs distributed in various regions of the world possess significant antiviral activities with no or limited adverse effects (McCutcheon et al, 1995;Vlietinck et al, 1995;Namba et al, 1998;Ma et al, 2002;Fernandez-Romero et al, 2003). Many naturally occurring compounds, such as flavonoids, tannins, caffeic acid derivatives, terpenoids and saponins, exhibit potent anti-HSV and anti-RSV activities in vitro and/or in vivo (Wyde et al, 1993;Namba et al, 1998;Kinjo et al, 2000;Cheng et al, 2002;Chiang et al, 2002;Ma et al, 2002). In the southern part of the People's Republic of China, the humid atmosphere and the warm climate make the availability of medicinal herbs abundant.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activities of medicinal herbs traditionally used in southern mainland China

Ooi

Wang

et al. 2004

Phytotherapy Research

101

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The aqueous extracts from 21 medicinal herbs traditionally used in southern mainland China were screened for antiviral activities against human herpes simplex virus type 1 (HSV-1) and human respiratory syncytial virus (RSV) using a cytopathic effect (CPE) reduction assay. Three extracts from Agrimonia pilosa, Pithecellobium clypearia and Punica granatum, respectively, showed anti-HSV-1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. Six of the extracts, from Blumea laciniata, Elephantopus scaber, Laggera pterodonta, Mussaenda pubescens, Schefflera octophylla and Scutellaria indica, respectively, exhibited anti-RSV activity with 50% inhibition (IC50) concentrations ranging from 12.5 to 32 microg/mL, and selective indices (SI) ranging from 11.2 to 40. In addition to polyphenolic compounds, other constituents present in these extracts may also contribute to their anti-RSV activity.

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Section: Introductionmentioning

confidence: 99%

Antiviral activities of medicinal herbs traditionally used in southern mainland China

Ooi

Wang

et al. 2004

Phytotherapy Research

101

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“…[2][3][4] In a preceding paper 5) we reported the in vitro anti-HSV-1 activity of some leguminous triterpenoidal saponins.…”

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confidence: 99%

Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids

Ikeda

Yokomizo

Okawa

et al. 2005

Biological & Pharmaceutical Bulletin

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“…The antiviral activity of soyasaponin against the herpes simplex virus, human immunodeˆciency virus, human cytomegalovirus, and FluV A has been reported. [8][9][10][11] Since it has been reported that soyasaponin was recovered in 70z aqueous ethanol, we presumed that the antiviral activity of the hot-water extract of black soybean against Ad1 would have come from compound(s) other than soyasaponin. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Since acute respiratory tract diseases are mainly caused by infection from viruses such as the adenovirus, in‰uenza virus, and coxsackievirus, 7) we have presumed that the pharmacological eŠect of the black soybean extract on the disease might be due to antiviral activity. Concerning the antiviral activity of soybean, it has been reported that soyasaponin from the common yellowish soybean inhibited the replication of the herpes simplex virus, 8,9) human immuno-deˆciency virus (HIV), 8,10,11) cytomegalovirus, 8) and in‰uenza virus. 8) However, the speciˆc antiviral activity of the black soybean extract against respiratory illness viruses has not been previously investigated.…”

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confidence: 99%