Anti-hepatitis C virus seropositivity is not associated with metabolic syndrome irrespective of age, gender and fibrosis

Cheng, Yuan-Lung; Wang, Yuan‐Chen; Lan, Keng‐Li; Huo, Teh Ia; Huang, Yi Hsiang; Su, Chien Wei; Lin, Han Chieh; Lee, Fa Yauh; Wu, Jaw Ching; Lee, Shou Dong

doi:10.1016/s1665-2681(19)30780-x

Cited by 21 publications

(17 citation statements)

References 28 publications

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“…However, the association between HCV infection and the development of MetS is still controversial. A previous hospital‐based study in Taiwan showed that although HCV was related to some metabolic derangements such as higher fasting glucose levels and lower cholesterol and TG levels, no significant association was found between HCV and MetS . Our previous study indicated that HCV subjects coexisting with MetS had higher liver stiffness level than those without MetS in the community, but HCV was not associated with MetS in multivariate analysis .…”

Section: Discussionmentioning

confidence: 86%

“…A previous hospital-based study in Taiwan showed that although HCV was related to some metabolic derangements such as higher fasting glucose levels and lower cholesterol and TG levels, no significant association was found between HCV and MetS. 13 Our previous study indicated that HCV | 999 subjects coexisting with MetS had higher liver stiffness level than those without MetS in the community, but HCV was not associated with MetS in multivariate analysis. 10 One review article also reported that HCV infection does not carry an increased risk of MetS, but it could affect glucose homoeostasis, causing both intrahepatic and extrahepatic insulin resistance.…”

Section: Factors Associated With Metabolic Syndrome In Lean Body Sumentioning

confidence: 79%

“…Apparently due to westernisation of the diet, the prevalence of MetS in Taiwan has been reported as having increased from 12% to 28% in recent decades . In addition, Taiwan is an HBV‐endemic area, and in its southern region, HCV infection is also prevalent .…”

Section: Introductionmentioning

confidence: 99%

“…12 Apparently due to westernisation of the diet, the prevalence of MetS in Taiwan has been reported as having increased from 12% to 28% in recent decades. 6,13 In addition, Taiwan is an HBV-endemic area, and in its southern region, HCV infection is also prevalent. 14 With the increase of MetS population in Taiwan, realising the relationship between MetS and chronic HBV or HCV infection is necessary.…”

Section: Introductionmentioning

confidence: 99%

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Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population‐based study

Kuo

Kee

Wang

et al. 2018

Aliment Pharmacol Ther

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Summary Background The impact of metabolic syndrome (MetS) on hepatitis is an interesting issue. Aim To evaluate the association of MetS and chronic viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in southern Taiwan. Methods From 2004 to 2013, a series of community‐based health screenings for residents aged 40 and older were held in Tainan city. MetS was defined according to the Joint Scientific Statement. Cut‐offs of body‐mass index measures of 24 kg/m2 and 27 kg/m2 were used to stratify lean, overweight and obese subjects. Results We enrolled 180 359 participants; the prevalence of MetS was 30.1%, which was significantly associated with advanced age and female sex. There were 18 726 (10.4%) HBV, 13 428 (7.4%) HCV, 1337 (0.7%) HBV plus HCV (B+C) and 146 868 (81.5%) non‐HBV non‐HCV participants (NBNC). Prevalence rates of MetS in subjects with HBV, HCV, B+C and NBNC were 25.2%, 31.5%, 28.9% and 30.7% respectively (P < 0.001). There were 18.8% lean body, 35.4% overweight and 45.8% obese participants among 54 361 MetS subjects. Lean MetS subjects were older, had more diabetes, and had higher metabolic component levels, but lower alanine transaminase and aspartate transaminase‐platelet ratio index levels compared with obese MetS subjects. HCV infection was positively associated with MetS (P < 0.001). However, HBV infection was inversely associated with MetS only among lean subjects (P = 0.002), but not among the general population. Conclusions This large population‐based study indicated that HCV infection was positively associated with MetS. However, HBV infection was inversely associated with MetS only among lean subjects.

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Section: Discussionmentioning

confidence: 86%

Section: Factors Associated With Metabolic Syndrome In Lean Body Sumentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population‐based study

Kuo

Kee

Wang

et al. 2018

Aliment Pharmacol Ther

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“…On the other hand, some studies reported neither an association between metabolic syndrome and HCV infection[18] nor reduced incidence of de novo glucose abnormalities in responders to treatment with interferon alpha and ribavirin[19]. …”

Section: Introductionmentioning

confidence: 99%

Retrospective study of the associations between hepatitis C virus infection and metabolic factors

Yair-Sabag

Nussinson

Ben‐Assuli

et al. 2016

WJH

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AIMTo evaluate the bidirectional association between metabolic syndrome (MS) components and antiviral treatment response for chronic hepatitis C virus (HCV) infection.METHODSThis retrospective cohort study included 119 HCV + patients treated with pegylated-interferon-α and ribavirin. Metabolic characteristics and laboratory data were collected from medical records. Differences in baseline clinical and demographic risk factors between responders and non-responders were assessed using independent samples t-tests or χ2 tests. The effects of sustained viral response (SVR) to antiviral treatment on de novo impairments in MS components, including impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), were assessed using univariable and multivariable logistic regression analysis, while the effect of MS components on SVR was assessed using univariable logistic regression analysis.RESULTSOf the 119 patients, 80 (67%) developed SVR over the average 54 ± 13 mo follow-up. The cumulative risks for de novo T2DM and IFG were 5.07- (95%CI: 1.261-20.4, P = 0.022) and 3.87-fold higher (95%CI: 1.484-10.15, P = 0.006), respectively for non-responders than responders, when adjusted for the baseline risk factors age, sex, HCV genotype, high viral load, and steatosis. Post-treatment triglyceride levels were significantly lower in non-responders than in responders (OR = 0.27; 95%CI: 0.069-0.962, P = 0.044). Age and HCV genotype 3 were significantly different between responders and non-responders, and MS components were not significantly associated with SVR. Steatosis tended to attenuate SVR (OR = 0.596; 95%CI: 0.331-1.073, P = 0.08).CONCLUSIONSVR was associated with lower de novo T2DM and IFG incidence and higher triglyceride levels. Patients infected with HCV should undergo T2DM screening and antidiabetic treatment.

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The association between metabolic syndrome and Hepatitis C virus infection in the United States

Rajkumar

Dwivedi

Dodoo

et al. 2020

Cancer Causes Control

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Anti-hepatitis C virus seropositivity is not associated with metabolic syndrome irrespective of age, gender and fibrosis

Cited by 21 publications

References 28 publications

Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population‐based study

Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: a large population‐based study

Retrospective study of the associations between hepatitis C virus infection and metabolic factors

The association between metabolic syndrome and Hepatitis C virus infection in the United States

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