Anti-hemolytic, Anti-lipid Peroxidation, Antioxidant Properties and Acute Toxicity of Xanthium strumarium Leaves Extracts

Guemmaz, Thoraya; Zerargui, Fatima; Boumerfeg, Sabah; Arrar, Lekhmici; Aouachria, Sana; Khennouf, Seddik; Charef, Noureddine; Baghiani, Abderrahmane

doi:10.9734/arrb/2018/40024

Cited by 17 publications

(21 citation statements)

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“…These results corroborated the biochemical and toxicological parameters [42]. Similarly, extracts of Xanthium strumarium and Xanthium sibiricum showed no toxicity in acute, subchronic, and chronic tests [37][38][39][40][41].…”

Section: Toxicity Of Medicinal Plants Containing Tomentosinsupporting

confidence: 78%

“…Although 13 medicinal species contain tomentosin in their extracts (Table 1), the toxicity of these plant extracts has only been investigated for three species; Dittrichia viscosa, Xanthium strumarium, and Xanthium sibiricum [37][38][39][40][41][42][43]. According to Tchaker and collaborators [43], aqueous extracts of Dittrichia viscosa (the species containing tomentosin as main compound) showed no toxicity.…”

Section: Toxicity Of Medicinal Plants Containing Tomentosinmentioning

confidence: 99%

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Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

et al. 2021

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Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as Inula viscosa. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agent

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Section: Toxicity Of Medicinal Plants Containing Tomentosinsupporting

confidence: 78%

Section: Toxicity Of Medicinal Plants Containing Tomentosinmentioning

confidence: 99%

Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

et al. 2021

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“…Total flavonoids were estimated using aluminum chloride colorimetric assay described by 11 Guemmaz et al(2018). To 1 ml of samples/standard, 1 ml of 2% aluminum chloride.…”

Section: Determination Of Total Flavonoidsmentioning

confidence: 99%

Anti-Inflammatory Potential Evaluation (In-Vitro and In-Vivo) of Arthrophytum scoparium Aerial Part

Kaddour¹,

Arrar²,

Baghiani³

2020

J. Drug Delivery Ther.

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Arthrophytum scoparium is plant commonly used in folk medicine in Algeria to treat numerous human diseases especially infectious, Rheumatism, diabetes and cancer. However, its anti-inflammatory activity and the underlying mechanisms have not been studied systematically. The present study aims to assess both the in vitro and in vivo anti-inflammatory potential and antioxidant activity of the plant. Results showed that A. scoparium chloroform extract (ChE) contains the largest amount of phenolic and flavonoid compounds. In-vitro bioassay consisted of investigating the effect of the plant extracts against protein denaturation (BSA and egg albumin). In-vivo anti-inflammatory activity was evaluated by measuring the percentage inhibition of carrageenan-induced rat paw edema after oral administration of the extracts. Results showed that inhibition of protein denaturation was maximum in case of A. scoparium crude extract (CrE) with dose dependant manner. Similarly in the in-vivo study, carrageenan induced inflammation was significantly antagonized by CrE with inhibition of 87.02% at 400 mg/kg. CrE extracts showed the highest scavenger effect against hydroxyl and hydrogen peroxide. The CrE showed potent anti-inflammatory activity in both the conditions in vivo and in vitro. In conclusion different A. scoparium extracts scavenged reactive oxygen species efficiently; it may be due to the presence of its flavonoids and polyphenols. These results support the traditional use of this plant. Keywords: Arthrophytum scoparium, polyphenols, anti-inflammatory activity, radical scavenging activity.

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“…Where AC: is the absorbance of the control (ABTS); AS: is the absorbance in the presence of the sample/ standard. β-Carotene/Linoleic Acid Assay: The capacity of plant extracts to anticipate bleaching of β -carotene was evaluated as described by Guemmaz et al 12 The solution mixture of β-carotene-linoleic acid was prepared as follows: 0.5 mg β-carotene was dissolved in 1 ml of chloroform and 25 μl linoleic acid and 200 mg tween 40. Chloroform was completely evaporated, and then, 100 ml distilled water saturated with oxygen were added.…”

Section: Abts + Scavenging Effect (%) = (Ac -As) / Ac × 100mentioning

confidence: 99%

Untitled

2019

IJPSR

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This study aims to evaluate the in-vitro and in-vivo antioxidant activity of different extracts prepared from the aerial parts of Arthrophytum scoparium. Polyphenols flavonoids and tannins contents were determined. The acute toxicity of ASE was carried out based on OECD during two weeks to ascertain the LD 50 . In sub-acute toxicity, a 100, 200 and 400 mg/kg/day extract was orally administrated for 21 days consecutively. The results showed that decoction extract (DEC) was the richest fractions in Polyphenols, flavonoids and tannins content (23.29 mg/GAE, 99.77 mg/QE and 113.33 mg/TAE), respectively. Arthrophytum scoparium hydromethanolic extract (ASE) had the strongest antioxidant activity using DPPH and ABTS scavenging assays with an IC 50 of 0.045 and 0.0017 mg/ml, respectively. Moreover, the β-carotene/linoleic acid bleaching assay showed that ethyl acetate extract (EAE) had the highest inhibiting activity (83.29%). Furthermore, all A. scoparium fractions exhibited a good ferric reducing power. The administrated doses did not undergo changes in general behavior, toxicity or mortality of the tested mice. The LD 50 was found to be superior to 5 g/kg. Daily administration of ASE leads to an increase in GSH level and decreasing the lipid peroxidation in the liver. In-vivo, ASE showed a strong scavenging effect on DPPH and reducing power. In conclusion, A. scoparium extracts exhibited considerable antioxidant effects in-vitro and in-vivo. These findings support the traditional use of this plant as an anti-inflammatory in therapeutics.

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Anti-hemolytic, Anti-lipid Peroxidation, Antioxidant Properties and Acute Toxicity of Xanthium strumarium Leaves Extracts

Cited by 17 publications

References 0 publications

Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

Anticancer and Anti-Inflammatory Effects of Tomentosin: Cellular and Molecular Mechanisms

Anti-Inflammatory Potential Evaluation (In-Vitro and In-Vivo) of Arthrophytum scoparium Aerial Part

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