Anti-Helicobacter Pylori Therapy in Primary MALT Lymphoma of Rectum

Sanctis, Vitaliana De; Marignani, Massimo; Angeletti, Stefano; Assisi, D.; Armosini, Veronica; Valeriani, Maurizio; Minniti, Giuseppe; Cox, Maria Christina; Ruco, Luigi; Enrici, Riccardo Maurizi

doi:10.1177/030089161209800423

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…The significance of eradication therapy for non-gastric intestinal MALT lymphomas is unclear, but there have been reports that rectal MALT lymphomas were eliminated following eradication therapy [17,18]. The H. pylori positivity rate among patients with gastric MALT lymphoma in this study was lower than that in previous studies [19].…”

Section: Discussioncontrasting

confidence: 66%

“…Several antibiotic regimens have been used for eradication therapy, such as proton pump inhibitors (PPIs) with clarithromycin and amoxicillin as first-line eradication therapy, and PPI with metronidazole and amoxicillin for second-line eradication therapy. Twenty-six patients with gastric MALT lymphoma and 4 patients with non-gastric intestinal MALT lymphoma underwent chromosomal analysis, but no characteristic t(11,18) mutations were detected.…”

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confidence: 99%

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Radiotherapy for non-gastric intestinal versus gastric MALT lymphoma: a comparison of treatment outcomes

Watanabe

Ogino

Hata³

2020

Blood Res

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Background: Radiotherapy is often used for treating patients with gastric mucosa-associated lymphoid tissue (MALT) lymphomas who fail to respond to Helicobacter pylori eradication. However, non-gastric intestinal MALT lymphoma is rare, and no standard therapeutic strategies have been established. This study was designed to assess the long-term prognosis of non-gastric intestinal MALT lymphoma treated with radiotherapy and to compare the outcomes with that of post-radiotherapy gastric MALT lymphoma. Methods: The study included 34 patients with stage I EA gastrointestinal MALT lymphoma according to the Ann Arbor classification who underwent definitive radiotherapy. The primary site was the rectum in 3, the duodenum in 1, and the stomach in 30 patients. The radiotherapy dose was 1.5-2.0 Gy (median, 1.5 Gy) and the total dose was 30-40 Gy (median, 30 Gy). The clinical target volume (CTV) was defined as the volume of the entire organ with the lymphoma. Adjacent lymph node areas were not routinely included in the CTV. Results: Complete response (CR) was achieved in all patients. There were no local recurrences, and two cases of recurrence were observed at other sites. The 5-year overall survival rates for non-gastric and gastric MALT lymphomas were 100% and 94.7%, respectively, and the 5-year disease-free survival rates were 100% and 95.7%, respectively. None of the patients died of the current illness. Conclusion: Radiotherapy for non-gastric intestinal MALT lymphoma is expected to result in good local control and long-term survival, similar to that for gastric MALT lymphoma.

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Section: Discussioncontrasting

confidence: 66%

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confidence: 99%

Radiotherapy for non-gastric intestinal versus gastric MALT lymphoma: a comparison of treatment outcomes

Watanabe

Ogino

Hata³

2020

Blood Res

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“…Isaacson and Wright firstly reported MALT lymphoma in 1983 [1], and treatment for cases in the stomach is well developed. Gastric MALT lymphoma has shown to be closely related to H. pylori infection [2][3][4][5][6], and antibiotic treatment to eradicate H. pylori is currently well recognized as the first line therapy for stage 1 or 2-1 (Lugano staging system) gastric MALT lymphoma.…”

Section: Introductionmentioning

confidence: 99%

A Case of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Treated Twice with Antibiotic Therapy for Helicobacter pylori.

Sakuraba¹,

Orita²,

Ito³

et al. 2018

J Can Sci Res

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Background: The effectiveness of treatment with antibiotic for mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach has been widely recognized in the last few decades. On the other hand, MALT lymphoma of the rectum is rare, and some literature has reported the usefulness of eradication of Helicobacter pylori, but the standard method of treatment has not been established. Case presentation: A 72 year old woman was referred to our department with submucosal tumor of the rectum. Colonoscopy revealed three flat elevation lesions on the right wall of the lower rectum and positron emission tomography-computed tomography (PET-CT) showed accumulation of fluorodeoxyglucose (FDG) in the same area. Pathological examination was compatible with MALT lymphoma. She was diagnosed with rectal MALT lymphoma. H. pylori infection was evaluated by gastrointestinal fiber and anti H. pylori IgG antibody serology, and her stomach was infected with H. pylori. Under her consent, we selected H. pylori eradication therapy as the first-line treatment. After first-line treatment, eradication of H. pylori was unsuccessful and the tumor had reduced in size but had not disappeared. We prescribed second-line treatment drugs and her tumor had disappeared completely and she had become negative for H. pylori. Now, she has no recurrence five years after the treatment. Conclusion: We treated a case of rectal MALT lymphoma with antibiotic therapy twice. Eradication of H. pylori was as useful for the rectum MALT lymphoma as it is for gastric MALT lymphoma. There are some reports that describe methods of treatment: surgical removal, medication, radiation, chemotherapy, and some cases had received more invasive therapy like surgical removal, radiation, and chemotherapy. In those cases, there were some instances in which medication was unsuccessful so the treatment was changed to more invasive therapy. There are controversial points about appropriate amount of time needed to determine additional treatment and the criteria for determination. Due to this lack of clarity, we reviewed the literature and speculate about them. We want to emphasize the point that administering antibiotic therapy twice or more might be useful to cases that did not respond to first line treatment and therefore had to receive more invasive therapy. Antibiotic treatment has fewer side effects than other types of therapy, so if it is useful, patients receive great benefits.

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Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

Kelley

2016

Int J Colorectal Dis

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Anti-Helicobacter Pylori Therapy in Primary MALT Lymphoma of Rectum

Cited by 5 publications

References 32 publications

Radiotherapy for non-gastric intestinal versus gastric MALT lymphoma: a comparison of treatment outcomes

Radiotherapy for non-gastric intestinal versus gastric MALT lymphoma: a comparison of treatment outcomes

A Case of Rectal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Treated Twice with Antibiotic Therapy for Helicobacter pylori.

Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

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