Anti-Helicobacter pylori activity and immunostimulatory effect of extracts from Byrsonima crassa Nied. (Malpighiaceae)

Abstract

Background: Several in vitro studies have looked at the effect of medicinal plant extracts against Helicobacter pylori (H. pylori). Regardless of the popular use of Byrsonima crassa (B. crassa) as antiemetic, diuretic, febrifuge, to treat diarrhea, gastritis and ulcers, there is no data on its effects against H. pylori. In this study, we evaluated the anti-H. pylori of B. crassa leaves extracts and its effects on reactive oxygen/nitrogen intermediates induction by murine peritoneal macrophages.

Peliminary examination of herbal extracts on the inhibition of <i>Helicobacter Pylori</i>

“…Dilution susceptibility testing method was used for MIC determination in reference to the cited literatures (Bonacorsi et al, 2009: CLSI, 2003 wherein, 160 μl of sterile Brucella broth media was decanted into first well and the other wells were fulled with 100 μl of sterile Brucella broth media. 40 μl of an 18-h old broth culture of H. pylori (McFarland's turbidity standard 2) suspension was added to the first well.…”

Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes

“…The antimicrobial compounds from plants may inhibit bacterial growth by different mechanisms than those of presently used antimicrobials and could therefore be of clinical value in the treatment of antibiotic-resistant microbial strains, including H. pylori (Bonacorsi et al, 2009). Many anti-H. pylori compounds exhibiting significant inhibitory effects including flavonoids, tannins, terpenes, aromatic aldehydes, alcohols, catechins, and quinones, have been identified from plant materials (Funatogawa et al, 2004;Nostro et al, 2005;Shin et al, 2005;Park et al, 2006).…”

“…However, this triple therapy is not always successful in eradicating the infection, and the acquisition of antibiotic resistance by H. pylori could reduce treatment efficacy and present a serious problem (Bonacorsi et al, 2009). As eradication therapies can be ineffective and undesirable side effects may occur, the search for new drugs for use in alternative therapies is very important (Stege et al, 2006;Zaidi et al, 2009).…”

Antimicrobial and anti-inflammatory activities of Apis mellifera honey on the Helicobacter pylori infection of Wistar rats gastric mucosa

“…In addition, according to Gharzouli et al (2002), the oral administration of honey hyperosmotic solutions increases the endogen prostacyclin in both antral and body mucosa of rats, optimizing cytoprotection and reducing the luminal pathogen population. Furthermore, the secretion of non-sulfhydryl proteins and endogen nitric acid by tissues treated by honey, and the high contents of phenolics/flavonoids in such nutraceutical supplement, which can clean the free superoxide and other oxygen reactive species (liberated during the respiratory explosion of the mucosa cells infected by H. pylori), helping in the protection of the mucin producing cells of the stomach, as well as acting as scavengers of nitric oxide, also contribute to its therapeutic potential (Gharzouli et al, 2002;Bonacorsi et al, 2009;Dwoyele et al, 2011).…”

“…Therefore, considering the level of efficiency, its high cost and side effects related, several researches have been carried out on natural products, either of vegetal or animal origin, aiming the detection and characterization of chemical compounds with antimicrobial and anti-inflammatory properties (Carson & Riley, 2003;Bonacorsi et al, 2009;Ayala et al, 2014). Plant and honey extracts are among the most attractive sources of new drugs and have shown promising results in gastric ulcer treatment, whose reduction rate, from the beginning of the treatment, serves as a marker of cure (Bonacorsi et al, 2009;Keenan et al, 2010).…”