Anti-HDV Seroprevalance Among Patients with Past HBV Infection

Abstract

OBJECTIVE:This prospective study aimed to determine the prevalence of anti-HDV seropositivity among subjects who had previous hepatitis B virus (HBV) infection.METHODS:Subjects who were admitted to the gastroenterology inpatient clinic of our hospital between August 2016 and July 2017 were screened for previous HBV infection. The subjects who had HBV serology compatible with resolved HBV infection were recruited in the study, and the seroprevalance of anti-HDV was studied. Participants answered a short questionnaire regarding their family history of chronic hepatitis B (CHB) and chronic hepatitis D (CHD) infection and risk factors for transmission. Subjects who were anti-HDV positive were recalled for a control visit, and HBV-DNA and HDV-RNA were assayed in the blood samples of the responders.RESULTS:Among 554 subjects who had previous HBV infection, 53 (9.6%) were anti-HDV positive. The mean age was 63.1±15.4 years in the anti-HDV-positive group and 65.9±15.6 years in the anti-HDV-negative group (p=0.19). The most common risk factor for both groups was dental procedures (89% vs 80%, p=0.33). Anti-Hbc IgG, anti-Hbs, and anti-HBeAg seropositivity did not differ between the anti-HDV-positive and -negative groups (for all, p>0.05). Although HDV-RNA was not detectable in all studied samples, only one subject had detectable HBV-DNA in the anti-HDV-positive group.CONCLUSION:This study highlighted the prevalence of anti-HDV among subjects who had resolved HBV infection. Long-term follow-up studies, including after the resolution of both infections, are needed to explore HBV–HDV interactions and the behavioral patterns of these viruses.

Sero-Prevalence of Hepatitis D Virus Infection Among Hepatitis B Surface Antigen Positive Patients in Mashhad, Northeastern Iran

“…The HDV infection rate was reported to be as high as 14.66% among 1890 HBV patients from east and northwest of Pakistan (22). Likewise, the prevalence rates of the infection in Turkey (9.6%) and Iraq (6.6%) were higher than the prevalence reported in the present study (23,24). Furthermore, an earlier study demonstrated a significantly higher HDV seroprevalence (26.66%) among Afghans who immigrated to Iran than among Iranian patients (1.85%) (25).…”

Prevalence of hepatitis D virus among HBsAg-positive individuals,2015-2016: Azar cohort study

“…In recent studies, the prevalence of HDV infection in HBsAg positive patients was reported to be 9.6% in Turkey and 6.6% in Iraq. 27,28 The differences in HDV prevalence between different countries may be related to variation in the prevalence of risk factors. Like HBV, transmissions from blood products, intravenous drug users, sexual behaviors and maternal-child transmission are the most prevalent rout of transmissions for HDV.…”

Hepatitis D Seroprevalence in people with chronic hepatitis B in Lubumbashi (DRC)

“…De la même manière, Makhlouf et al (2019) ont rapporté une séroprévalence anti-VHD de 43% chez des patients hospitalisés dans une institution hospitalière d 'Egypte, alors qu'au Burkina Faso, Sawadogo et al (2016) rapportent une séroprévalence anti-VHD de 3,38% dans une population de donneurs de sang porteurs de l'AgHBs au centre régional de transfusion sanguine de Bobo-Dioulasso. D'autre part, Sahin et al (2018) ont rapporté une séroprévalence anti-VHD de 9,6% chez les sujets AgHBs positif dans une zone d'endémie en Turquie, alors que Ifeorah et al (2017) avancent une séroprévalence de 7,1% dans une étude réalisée à Abuja au Nigéria chez les personnes infectées par le VIH et vivant avec l'hépatite B.…”

“…Le virus de l'hépatite D (VHD) est un virus à ARN simple brin d'environ 1,7 kb, et est le seul membre de la famille des Deltaviridae (genre Deltavirus) (Daw et al, 2018). Le VHD nécessite les protéines de surface (AgHBs) de VHB pour constituer les particules virales infectieuses (Abdulazeez et al, 2014 ;Lozes et al, 2016 ;Sawadogo et al, 2016 ;Sahin et al, 2018 ;Makhlouf et al, 2019). Les patients présentant une infection chronique à VHB constituent le principal groupe susceptible de surinfection par le VHD, bien que les coinfections sont aussi décrites (Njemanze et al, 2009 ;Botelho-Souza et al, 2017 ;Chen et al, 2018 ;Sanou et al, 2018).…”