Abstract:Individuals infected with hepatitis C virus (HCV) usually produce anti-HCV antibodies detectable by enzyme immunoassay (EIA); however, in certain viremic cases this antibody does not appear. To investigate whether anti-HCV in these cases is detectable by Western blot (WB), 38 HCV RNA positive/anti-HCV EIA-negative sera were tested by RIBA 3.0 or LiaTek III. The HCV genotypes (INNO-LiPA) were analyzed to determine whether the variance in these genotypes can be the reason for the late, weak antibody production o… Show more
“…Seroreversion spontaneously (31, 32) following acute hepatitis C (33), or with therapy after a needlestick injury has also been described (34, 35). The decrease or disappearance of HCV antibodies may be predictive of self‐limited infection.…”
One-quarter of the SR showed seroreversion of anti-HCV and weaker CD4+ specific HCV proliferation than those who remained anti-HCV positive. The data suggest that complete viral eradication is a possible and achievable clinical objective.
“…Seroreversion spontaneously (31, 32) following acute hepatitis C (33), or with therapy after a needlestick injury has also been described (34, 35). The decrease or disappearance of HCV antibodies may be predictive of self‐limited infection.…”
One-quarter of the SR showed seroreversion of anti-HCV and weaker CD4+ specific HCV proliferation than those who remained anti-HCV positive. The data suggest that complete viral eradication is a possible and achievable clinical objective.
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