Anti-HCV positive patients in dialysis units?

Gilli, P; Moretti, Michèle; Soffritti, Silvia; Menini, C; Mondelli, Mario U.; Cristina, Giovanni; Filice, G.; Rondanelli, E. G.; Piazza, V.; Barbieri, Cristiana

doi:10.1016/0140-6736(90)91766-4

Cited by 30 publications

(8 citation statements)

References 7 publications

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“…A prevalence of hepatitis C antibodies of 12% in hemodialysis patients as found in the total sample in our region is of the same order as reported from other parts of western Europe, the United States, and Japan [Esteban et al, 1989;Gilli et al, 1990;Jeffers et al, 1990;Hayashi et al, 19911. There is, however, considerable variation among the units, where from zero to 22% of the patients show antibodies against HCV.…”

Section: Discussionsupporting

confidence: 89%

Hepatitis C virus infection in hemodialysis patients in southern Sweden: Epidemiological, clinical, and diagnostic aspects

Nordenfelt

Löfgren

Widell

et al. 1993

Journal of Medical Virology

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A prevalence of hepatitis C virus (HCV) antibodies of 12% was found in 276 patients from 11 dialysis units. Between zero and 22% of the patients in the different units were anti-HCV positive. The epidemiology of HCV was studied in two units during a 2 year period by antibody assays and the polymerase chain reaction and correlated with clinical manifestations. Two types of epidemiologic patterns were found that may explain the wide difference of HCV prevalence described in different dialysis units. In one unit there was no evidence of spread within the unit, and the prevalence of HCV was dependent on the status of the patients entering for treatment. In the other unit, a clustering of infected patients could be seen in which 13 of 36 were infected during a 3 year period. Some patients who had not received blood transfusions were among the infected. Hepatitis C infection was the most common explanation for repeated abnormal transferase levels. Most of the HCV-infected patients reacted both for anti-HCV and HCV RNA. HCV RNA was in general detected earlier than anti-HCV seroconversion. Among 20 HCV RNA-positive serum samples that were anti-HCV ELISA-positive 18 had indeterminate and two negative reactions by immunoblot (RIBA 2). Thus the RIBA 2 test should be used with caution as a confirmatory antibody test in this group of patients.

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Section: Discussionsupporting

confidence: 89%

Hepatitis C virus infection in hemodialysis patients in southern Sweden: Epidemiological, clinical, and diagnostic aspects

Nordenfelt

Löfgren

Widell

et al. 1993

Journal of Medical Virology

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“…Some authors recommended that it is sufficient to treat every dialysis patient as potentially infectious, strictly adhering to the "universal precautions for prevention of HCV transmission", to prevent the spread of HCV in dialysis units [32,33] and isolation of HCV-infected dialysis patients and use of dedicated machines are unjustified [34]. P. Gilli et al demonstrated that machine separation in the presence of strict application of hygienic precautions did not reduce HCV transmission [35].…”

Section: Discussionmentioning

confidence: 99%

The role of hemodialysis machines dedication in reducing Hepatitis C transmission in the dialysis setting in Iran: A multicenter prospective interventional study

et al. 2004

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“…Other parenteral routes of transmission include haemodialysis,17 18 organ transplantation,19tattooing, and in certain countries traditional practices using non-sterilised knives and indeed the use of non-sterilised needles in large scale immunisation programmes may have contributed to the spread of HCV in these communities. Transmission has also been documented following needlestick injuries (risk estimated 1.8%; CDC 1997) but the frequency of seroconversion following needlestick exposure seems to be low,20 and the prevalence of HCV infection in health workers is no greater than in the general population 21…”

Section: 0 Backgroundmentioning

confidence: 99%