2024
DOI: 10.1590/1519-6984.252676
|View full text |Cite
|
Sign up to set email alerts
|

Anti HCV activity and expression inhibition of HCC markers by protein extract from Iberis gibraltarica

Abstract: Hepatitis C virus infection (HCV) is the foremost reason of progressive hepatic fibrosis and cirrhosis, with an elevated risk of hepatocellular carcinoma (HCC) development. Medicinal plants have been used for human health benefits for several years, but their therapeutic potential needs to be explored. The main objective of this study was to figure out the in vitro antiviral and anticancer characteristics of total crude protein of Iberis gibraltarica against HCV and HCC. Total crude protein of Iberis gibraltar… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 47 publications
0
2
0
Order By: Relevance
“…On the other hand, the effect of the Iberis gibraltarica protein extract was analyzed on HepG2 cells infected with hepatitis C virus (HCV), obtaining that the total protein reduces the RNA of the virus by 20, 48 and 60 % when using concentrations of 30, 60 and 90 μg/mL. [25] In addition, two compounds isolated from the methanolic extract of Dracaena cinnabari were analyzed, and the results of both showed a dose-dependent decrease in the expression of the HBsAh protein of the hepatitis B virus (HBV) in HepG2.2.2.15 cells. In addition, HBV replication was decreased by 26.7 % and 38.2 % three days post-treatment.…”
Section: Antiviral Activitymentioning
confidence: 99%
“…On the other hand, the effect of the Iberis gibraltarica protein extract was analyzed on HepG2 cells infected with hepatitis C virus (HCV), obtaining that the total protein reduces the RNA of the virus by 20, 48 and 60 % when using concentrations of 30, 60 and 90 μg/mL. [25] In addition, two compounds isolated from the methanolic extract of Dracaena cinnabari were analyzed, and the results of both showed a dose-dependent decrease in the expression of the HBsAh protein of the hepatitis B virus (HBV) in HepG2.2.2.15 cells. In addition, HBV replication was decreased by 26.7 % and 38.2 % three days post-treatment.…”
Section: Antiviral Activitymentioning
confidence: 99%
“…The World Health Organization (WHO)'s global hepatitis strategy aims to reduce new hepatitis infections by 90% and deaths by 65% between 2016 and 2030. Hepatitis C virus (HCV) belong to the Hepacivirus genus, with six major genotypes, which can cause liver disease (Lindenbach and Rice, 2005;Bilal, et al, 2022). Determination of HCV genotypes and subtypes are important to predict response to antiviral therapy for the efficacy and barrier to resistance of non-pangenotypic direct-acting antiviral agents (DAAs) depend on the HCV genotypes and subtypes (Hayes, et al, 2022).…”
Section: Introductionmentioning
confidence: 99%