Anti-HBs Titers Following Pentavalent Immunization (DTwP-HBV-Hib) in Term Normal Weight vs Low Birthweight Infants

Verma, Chandrika; Faridi, M. M. A.; Narang, Manish

doi:10.1007/s13312-018-1280-x

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Administration of birth dose to the PT2 infants did not significantly influence antibody positivity/titers. Comparable anti-HBs response in full term, normal weight and underweight Indian infants was documented after receiving hepatitis B vaccine at birth and pentavalent vaccination as per recommended schedule (33). The data suggests that rather than birth weight, gestational age plays crucial role in deciding immune response.…”

Section: Discussionmentioning

confidence: 94%

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

et al. 2021

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Childhood vaccination plays critical role in protecting infants from several dreaded diseases. Of the global 15 million preterm (PT) infants with compromised immune system born annually, India contributes to >3.5 million. Generation of adequate vaccine-induced immune response needs to be ensured of their protection. Immune response of Indian PT (n = 113) and full-term (FT, n = 80) infants to pentavalent vaccine administered as per the national recommendation was studied. Antibody titers against component antigens of pentavalent vaccine, immune cells profiling (T and B cells, monocytes and dendritic cells) and plasma cytokines were determined pre- and post-vaccination. Additionally, cell-mediated recall immune responses to pentavalent antigens were evaluated after short time antigenic exposure to infant PBMCs. Irrespective of gestational age (GA), all the infants developed adequate antibody response against tetanus, diphtheria, and protective but lower antibody levels for Haemophilus influenzae type-b and hepatitis B in preterm infants. Lower (~74%) protective antibody response to pertussis was independent of gestational age. PT-infants exhibited lower frequencies of CD4 T cells/dendritic cells/monocytes, increased plasma IL-10 levels and lower proliferation of central and effector memory T cells than in term-infants. Proliferative central memory response of FT-infants without anti-pertussis antibodies suggests protection from subsequent infection. Responder/non-responder PT-infants lacked immunological memory and could be infected with Bordetella. For hepatitis B, the recall response was gestational age-dependent and antibody status-independent. Humoral/cellular immune responses of PT-infants were dependent on the type of the immunogen. Preterm infants born before 32 weeks of gestation may need an extra dose of pentavalent vaccine for long lived robust immune response.

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Section: Discussionmentioning

confidence: 94%

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

et al. 2021

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“…Routine childhood vaccinations have been shown to be safe, immunogenic and effective for preterm and LBW infants, providing protection against Vaccine-Preventable-Diseases (VPD). [18][19][20][21][22][23][24][25] Yet, considerable gaps in routine vaccination timeliness and completeness have been evident when comparing LBW and preterm infants to term infants. Vaccination delays tend to be greater when the preterm infants are born earlier and with lower birthweights.…”

Section: Introductionmentioning

confidence: 99%

Vaccination timeliness and completeness among preterm and low birthweight infants: a national cohort study

Bary-Weisberg

Stein‐Zamir

2020

Human Vaccines & Immunotherapeutics

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Vaccinating premature and low birthweight (LBW) infants according to chronological age has been found safe and effective. Although these infants are susceptible to infections, vaccinations are often delayed. We estimated vaccination coverage (VC) in preterm and LBW infants compared to term infants in a cohort study (2016 Israel birth cohort, n = 181,543) using the National Immunization Registry. Vaccinations included Hepatitis B, Diphtheria-Tetanus-acellular Pertussis-IPV-Haemophilus influenzae B, Oral Polio Bivalent, Rotavirus, Pneumococcal Conjugate, Measles-Mumps-Rubella-Varicella and Hepatitis A. Inclusion criteria: (1) born in Israel; (2) having a unique identifier (allowing data matching); and (3) surviving to 24 months. VC at 24 months and timeliness of vaccine doses were evaluated according to infants’ birthweight (BW) and gestational age (GA). Preterm infants (GA < 37 weeks) comprised 7.0% (n = 12,264); LBW infants (BW< 2500 g) were 7.7% (n = 13,950); BW was 1500–2499 g in 6.8%, 1000–1499 g in 0.6% and below 1000 g in 0.3%. Compared to normal birthweight (NBW) infants (BW≥2500 g), LBW infants showed delayed initiation of vaccinations. Odds ratio (OR) for delay: DTaP-IPV-Hib 1 OR = 1.26 [95%CI 1.19–1.33]; Rota 1, OR = 1.22 [95%CI 1.16–1.29]. Vaccination delay rates were higher among smaller new-borns (below 1000 g). At 24 months there was no significant difference regarding vaccination status. This national cohort VC analysis focused on preterm/LBW infants. Vaccinating preterm and LBW infants according to the recommended schedule induces protection against life-threatening infectious diseases. Vaccination initiation among LBW infants showed considerable delay. Health practitioners and parents should cooperate to improve timely vaccination initiation.

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“…After introduction of hexavalent vaccines in late 2000 in Germany (23), HBsAb titer ≥ 10 mIU/mL showed that vaccination might cause an acceptable 90% long-term protection of 5 -20 years after primary immunization (5). Verma et al studied antibody levels in 218 low birth weight and 265 normal birth weight infants that received pentavalent vaccine at six, ten, and fourteen weeks after birth; six weeks after the third dose of pentavalent vaccine, satisfactory antibody levels were observed in both groups (24). Their study showed more acceptable antibody level in children vaccinated with pentavalent at the lower age than the current study.…”

Section: Discussionmentioning

confidence: 43%

Hepatitis B s-Antigen Seroconversion Rate After Primary Immunization Series with Newly Introduced Pentavalent Vaccine: A Report of Regional Study in Alborz Province, Iran, 2016

Arjmand¹,

Golami

Shirvani

et al. 2019

Arch Pediatr Infect Dis

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Background: Since November 2014, pentavalent vaccine is available in Iran. This vaccine should be injected into all Iranian children at two, four, and six months after birth. Objectives: There is little information on the immunogenicity of this vaccine against hepatitis B (HB) in Iranian children; therefore, the current study aimed at investigating the vaccine efficacy six months after administration of the last dose. Methods: A total of 400 blood samples were collected from one-year-old children referred to Karaj healthcare centers, Alborz province, Iran. After sampling, checklists of demographic information were completed. Blood samples were sent to the laboratory to determine antibody titer by CMIA (chemiluminescent microparticle immunoassay). Statistical analysis was conducted by Stata and SVY software. Results: Overall, 393 (98.3%) children (95% confidence interval (CI): 96.03%-99.57%) had a protective IgG titer of > 10 mIU/mL, while it was < 10 mIU/mL in seven (95% CI: 0.5%-3.1%) subjects. Geometric mean titer was 419.66 mIU/mL (95% CI: 380.52-462.82). Anti-HBsAb titer was not associated with gender and the type of milk feeding. Conclusions: The seroprotection of HB vaccine in a pentavalent combination vaccine in Iran, six months after three doses of vaccination, was acceptable.

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Anti-HBs Titers Following Pentavalent Immunization (DTwP-HBV-Hib) in Term Normal Weight vs Low Birthweight Infants

Abstract: Three primary doses of pentavalent vaccine administered along with zero dose of Hepatitis B vaccine at birth provide good seroprotection. The vaccine appears to be safe in both low birth weight and normal birthweight infants born at term.

Cited by 5 publications

References 14 publications

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age

Vaccination timeliness and completeness among preterm and low birthweight infants: a national cohort study

Hepatitis B s-Antigen Seroconversion Rate After Primary Immunization Series with Newly Introduced Pentavalent Vaccine: A Report of Regional Study in Alborz Province, Iran, 2016

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