Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft

Abstract

These data support the use of marginal organs in this setting, providing a potential strategy to further alleviate organ shortage.

Liver transplantation from hepatitis B surface antigen positive donors: A safe way to expand the donor pool

“…The clinical and sero-virological course of this patient is very similar to that of the second patient (case 2, Fig. 1), already described as a case report with a shorter follow-up [13]. The third patient, a woman transplanted for HCC on HCV-related cirrhosis, died after 12 months from OLT because of severe fibrosing cholestatic HCV hepatitis (case 5, Fig.…”

“…Data were collected from OLT until the last follow-up visit and the median follow up after OLT was 42 months (range 12-60). One patient (case 2, Table 1) has already been described as a case report [13].…”

Immune Response in Hepatitis B Virus Infection

“…CHB patients receiving bone marrow transplants from HBV-immune donors were cured. Likewise, transplantation of an HBV-infected liver into a recipient who previously recovered from HBV infection resulted in viral control (Loggi et al 2009). Thus, gene therapy approaches might have great potential, but safety concerns, cost, and ethical issues related to viral vector use need to be addressed.…”

HBV life cycle and novel drug targets

“…Based on these observations, a sustained reconstitution of HBV-specific immunity in chronically infected patients could be a rational strategy for the control of chronic HBV infection. This is impressively supported by the observation that patients with chronic HBV infection can efficiently control the infection after bone marrow transplantation from donors with natural immunity to HBV [79][80][81].…”