Anti-GQ1b antibody syndrome presenting as acute isolated bilateral ophthalmoplegia: Report on two patients and review of the literature

Acute Ophthalmoplegia; Same Disease, Different Variants: Anti GQ1b Antibody Syndrome

“…MFS is an inflammatory neuropathy with clear consciousness and BBE is a central nervous system disease characterized by consciousness disturbance. Acute ophthalmoplegia can be seen in both BBE and MFS and it is associated with the presence of ganglioside GQ1b and called Anti GQ1b Antibody syndrome (3,4). We describe two patients admitted at the same time with bilateral ophthalmoplegia.…”

Headache and Ophthalmoparesis: Case Report of an “Atypical” Incomplete Miller–Fisher Syndrome

“…These similarities and their shared common causative factor have led to the definition of term “anti‐GQ1b antibody syndrome.” GQ1b gangliosides are highly expressed in the 3 cranial oculomotor nerves and the deep cerebellar nuclei, suggesting an important role of anti‐GQ1b antibodies in the pathogenesis of MFS and explaining their association with ophthalmoplegia in both BBE and MFS . Rare cases of atypical MFS with anti‐GQ1b antibodies presenting as acute ophthalmoparesis (AO) without ataxia or areflexia have been described . Although back and limb pain has been frequently reported in GBS, headache is a rare condition in these disorders .…”

“…1,2 Rare cases of atypical MFS with anti-GQ1b antibodies presenting as acute ophthalmoparesis (AO) without ataxia or areflexia have been described. [3][4][5][6][7] Although back and limb pain has been frequently reported in GBS, headache is a rare condition in these disorders. 8 We describe a case presenting with headache as the first symptom of an anti-GQ1b antibody syndrome with isolated ophthalmoparesis.…”

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“…3,7 Editor Miller-Fisher syndrome (MFS) is an acute polyradiculoneuritis considered as a variant form of Guillain-Barré syndrome (GBS). 1 MFS accounts for about 5% of GBS cases. 2 The clinical triad of MFS is characterized by ophthalmoplegia, ataxia and areflexia.…”