Anti-glycation properties of the aqueous extract solutions of dried algae products and effect of lactic acid fermentation on the properties

Kuda, Takashi; Eda, Mika; Kataoka, Manami; Nemoto, Maki; Kawahara, Miho; Oshio, Satoshi; Takahashi, Hiroki; Kimura, Bon

doi:10.1016/j.foodchem.2015.07.073

Cited by 47 publications

(17 citation statements)

References 32 publications

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“…Many natural compounds have been described to have therapeutic effects in preventing MG‐induced glycation, mainly due to MG‐scavenging and antioxidant properties, also increasing GLO1 activity. There are immense studies addressing this issue and a myriad of compounds including soy isoflavones, δ‐tocopherol, several flavonoids, phenols, xantonoids, and diterpenes and triterpenes from fruit and vegetables, phlorotannins, olive oil, polyunsaturated free fatty acids, and diverse plant, root and algae‐extracted compounds have been previously tested in in vitro and in vivo models of hyperglycemia and in presence of MG‐derived AGE. Such compounds were found to prevent from protein glycation by scavenging MG and, some of them, by activating GLO1.…”

Section: The Promise Of New Therapeutic Targetsmentioning

confidence: 99%

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

Matafome

Rodrigues

Sena

et al. 2016

Medicinal Research Reviews

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Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal (MG), which is a strong precursor of advanced glycation end products (AGE). The MG has been implicated in classical diabetic complications such as retinopathy, nephropathy, and neuropathy, but has also been recently associated with cardiovascular diseases and central nervous system disorders such as cerebrovascular diseases and dementia. Recent studies even suggested its involvement in insulin resistance and beta-cell dysfunction, contributing to the early development of type 2 diabetes and creating a vicious circle between glycation and hyperglycemia. Despite several drugs and natural compounds have been identified in the last years in order to scavenge MG and inhibit AGE formation, we are still far from having an effective strategy to prevent MG-induced mechanisms. This review summarizes the endogenous and exogenous sources of MG, also addressing the current controversy about the importance of exogenous MG sources. The mechanisms by which MG changes cell behavior and its involvement in type 2 diabetes development and complications and the pathophysiological implication are also summarized. Particular emphasis will be given to pathophysiological relevance of studies using higher MG doses, which may have produced biased results. Finally, we also overview the current knowledge about detoxification strategies, including modulation of endogenous enzymatic systems and exogenous compounds able to inhibit MG effects on biological systems.

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Section: The Promise Of New Therapeutic Targetsmentioning

confidence: 99%

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

Matafome

Rodrigues

Sena

et al. 2016

Medicinal Research Reviews

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“…Specifically, C. vulgaris and A. platensis aqueous extracts and silk sericin were spray dried, alone or combined, to obtain five microsphere formulations (Chl, Art, Ser, Chl-Ser and Art-Ser). The aqueous extraction of both microalgae was performed to obtain a pool of phytochemicals that have synergistic or additive effects as reported in literature [ 25 ], particularly against the oxidative stress. Sericin, due to its wound healing potential [ 18 ], may improve the regenerative effect of the microalgae extracts; moreover, it represents an adequate polymeric carrier [ 36 ] for the microencapsulation process of algal extracts.…”

Section: Discussionmentioning

confidence: 99%

“…Microalgae were added to distilled water (2.5% w / v ) and heated at 105 °C for 15 min in autoclave (Auclave 760, Asal Srl, Milan, Italy). After cooling, microalgae suspensions were centrifuged at 3000× g for 10 min and the algal aqueous extracts [ 25 ] were collected. Known volumes of both extracts were dried in a stove to calculate the final concentrations.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Effectiveness of Microspheres Based on Silk Sericin and Chlorella vulgaris or Arthrospira platensis for Wound Healing Applications

et al. 2017

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Some natural compounds have recently been widely employed in wound healing applications due to their biological properties. One such compound is sericin, which is produced by Bombix mori, while active polyphenols, polysaccharides and proteins are synthetized by Chlorella vulgaris and Arthrospira platensis microalgae. Our hypothesis was that sericin, as an optimal bioactive polymeric carrier for microencapsulation process, could also improve the regenerative effect of the microalgae. A solvent-free extraction method and spray drying technique were combined to obtain five formulations, based on algal extracts (C. vulgaris and A. platensis, Chl and Art, respectively) or silk sericin (Ser) or their mixtures (Chl-Ser and Art-Ser). The spray drying was a suitable method to produce microspheres with similar dimensions, characterized by collapsed morphology with a rough surface. Art and Art-Ser showed higher antioxidant properties than other formulations. All microspheres resulted in cytocompatibility on fibroblasts until 1.25 mg/mL and promoted cell migration and the complete wound closure; this positive effect was further highlighted after treatment with Art and Art-Ser. To our surprize the combination of sericin to Art did not improve the microalgae extract efficacy, at least in our experimental conditions.

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“…The lysine-glucose Maillard reaction was determined as recorded previously [33]. Glutamic acid and lysine (both at 1.0 M, 0.2 mL) were mixed with 0.8 mL of tested samples in sodium phosphate buffer (0.1 M, pH 6.8) and 0.5 mL of 0.25 M sodium phosphate buffer at 70 °C for 2 hours.…”

Section: Anti-glycation Assaymentioning

confidence: 99%

Fermentation of Danggui Buxue Tang, an ancient Chinese herbal mixture, together with Lactobacillus plantarum enhances the anti-diabetic functions of herbal product

Guo

Gao

et al. 2020

Preprint

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Background Danggui Buxue Tang (DBT), an ancient Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix at a ratio of 5: 1, is prescribed for menopausal women. Flavonoids and its flavonoid glycosides are considered as the major active ingredients within the herbal decoction; however, their amount is not controllable during the preparation. Besides, the aglycons within DBT are believed to have better gut absorption and pharmacological efficacy. Methods In order to enhance the therapeutic efficacy of DBT, the herbal extract was fermented together with Lactobacillus plantarum, a Gram-positive Lactobacillus commonly found in fermented food products. Results The fermentation of DBT with L. plantarum drove a completed conversion of calycosin-7-O-β-D-glucoside and ononin to calycosin and formononetin, respectively, as determined by UPLC-MS/MS analysis. The chemical transformation could be probably mediated by β-glycosidase within the fermented product. Several in vitro assays corresponding to anti-diabetic functions were compared between parental DBT against its fermented product, which included the activities against α-glucosidase, α-amylase and lipase, as well as anti-oxidation (e.g. DPPH radical-scavenging and total antioxidant capacities) and anti-glycation (e.g. BSA-methylglyoxal, BSA-fructose and arginine-methylglyoxal models). The fermented DBT showed increased activities in inhibiting α-glycosidase, suppressing DPPH radical-scavenging and anti-glycation, as compared to the original herbal product. Conclusion The results supported the possible application of L. plantarum or other Lactobacillus in fermenting herbal extract, as such to increase the yield and efficacy of the final products.

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Anti-glycation properties of the aqueous extract solutions of dried algae products and effect of lactic acid fermentation on the properties

Cited by 47 publications

References 32 publications

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

In Vitro Effectiveness of Microspheres Based on Silk Sericin and Chlorella vulgaris or Arthrospira platensis for Wound Healing Applications

Fermentation of Danggui Buxue Tang, an ancient Chinese herbal mixture, together with Lactobacillus plantarum enhances the anti-diabetic functions of herbal product

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