Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum

Abstract

Tripolinolate A as a new bioactive phenolic ester was previously isolated from a halophyte of . However, the and anti-glioma effects and mechanism of tripolinolate A have not been investigated. This study has demonstrated that (1) tripolinolate A inhibited the proliferation of different glioma cells with IC values of 7.97 to 14.02 µM and had a significant inhibitory effect on the glioma growth in U87MG xenograft nude mice, (2) tripolinolate A induced apoptosis in glioma cells by downregulating the expressions of antiapoptotic proteins and arrested glioma cell cycle at the G/M phase by reducing the expression levels of cell cycle regulators, and (3) tripolinolate A also remarkably reduced the expression levels of several glioma metabolic enzymes and transcription factors. All data together suggested that tripolinolate A had significant and anti-glioma effects and the regulation of multiple tumor-related regulators and transcription factors might be responsible for the activities of tripolinolate A against glioma.

Harnessing the Value of Tripolium pannonicum and Crithmum maritimum Halophyte Biomass through Integrated Green Biorefinery

“…Yields of aqueous or ethanol extracts from sea aster have not been previously widely reported, but Wubshet et al [39] obtained an 8.3% yield in maceration with 70% methanol. Wisznieska et al [58] reported that salt stress increases the amount of soluble carbohydrates in sea aster biomass.…”

“…They can be efficiently grown in hydroponic and aquaponic systems, and they have shown potential for cultivation in degraded soils and marginal land areas [25,[28][29][30][31]. The extracts from these plants have been reported to have antioxidant, anti-inflammatory, antimicrobial, antiviral, antifungal, neuro-protective, anti-diabetic, and antitumor properties [21,[32][33][34][35][36][37][38][39][40][41]. In folk medicine, sea fennel was used for its diuretic properties, parasite prevention, and in case of digestive issues; sea aster was used as an expectorant to relieve cough [26,41,42].…”

Prospects of marine-derived compounds as potential therapeutic agents for glioma

“…(Asteraceae) halophyte, inhibited the proliferation of different glioma cells with IC 50 values of 7.97–14.02 µM and had a significant inhibitory effect on the glioma growth in U87MG xenograft nude mice (Chai et al. 2018 ). In conclusion, a growing body of research demonstrates that marine-derived substances inhibit glioma cell proliferation and exhibit antitumour effects.…”

Cultivation and characterisation of Salicornia europaea, Tripolium pannonicum and Crithmum maritimum biomass for green biorefinery applications

“…High-value bioactive compounds suitable for cosmetics and pharmaceutical ingredients can also be found from Salicornia spp. 27 , 29 – 32 , Tripolium pannonicum 33 , 34 and Crithmum maritimum 35 , 36 extracts, and these compounds have exhibited antioxidant activity, anti-inflammatory and antimicrobial effects, anti-obesity properties, and even cancer-preventing capabilities.…”